Abstract：Insulin, the only hormone in human body that decreases blood glucose, plays an important role in diabetes treatments. Currently, as a biopharmaceutics, it is mostly administrated by injections. Moreover, frequent dosing is required because of its short half-life, bringing great pain to patients.The transdermal drug delivery system is one of orientations, which can avoid enzymatic degradation caused by gastrointestinal absorption in noinvasive way. However, due to the skin barrier, it is difficult for insulin to pass through the skin to achieve therapeutic effects.Microneedle,a novel transdermal technology, can establish micron-scale drug delivery channels to corium layer, and enhance drug permeability especially macromolecular drugs. In recent years, more and more studies focus on microneedle technology to efficiently and safely transport insulin. Thus, we will briefly summarize the types of microneedles, and introduce the mechanism of smart insulin microneedle delivery systems which can respond to changes of blood glucose concentration.
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