Rationality Analysis of the Treatment of Coronavirus Disease 2019 (COVID-19) with Reduning Injection
GUO Si-rui, ZHAO Zi-nan, JIN Peng-fei, ZHANG Bi-hua, WU Xue-jun, ZHANG Shan-shan, HU Xin*
Department of Pharmaceutical Science, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Science, Beijing Key Laboratory of Drug Clinical Risk and Personalized Medication Evaluation, Beijing Hospital, Beijing 100730, China
Abstract：OBJECTIVE To evaluate the safety and rationality of Reduning injection in the treatment of COVID-19. METHODS Through consulting, summarizing and analyzing literatures, the rapid HTA evaluation of Reduning was carried out, and its pharmacological rationality and drug monitoring for COVID-19 were discussed. RESULTS Literature analysis indicated that COVID-19 belongs to the pestilence of TCM. It was characterized by “dampness, heat, deficiency, toxin and stasis”, and its clinical manifestations involved inflammatory factor storm, immune system damage, etc. Reduning injection was approved to the treatment of influenza, cough and respiratory tract infections caused by exopathic wind-heat, and a typical drug for heat-clearing and detoxifying. CONCLUSION The rapid HTA evaluation showed that Reduning injection has good safety, effectiveness and economy. The mechanisms of Reduning in antipyretic and anti-inflammatory, immune regulation and anti-virus suggest the rationality of Reduning in treating COVID-19, but drug monitoring should be done well in the use process.
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2020, Vol. 55 
