吡唑并嘧啶衍生物合成及其活性研究进展

张美荣,刘举*,张新威,周云鹏,陈烨,王洋,徐利锋

中国药学杂志 ›› 2015, Vol. 50 ›› Issue (3) : 194-200.

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中国药学杂志 ›› 2015, Vol. 50 ›› Issue (3) : 194-200. DOI: 10.11669/cpj.2015.03.002
综述

吡唑并嘧啶衍生物合成及其活性研究进展

  • 张美荣,刘举*,张新威,周云鹏,陈烨,王洋,徐利锋
作者信息 +

Research Progress of Synthesis and Pharmacological Activity of Pyrazolo Pyrimidine Derivatives

  • ZHANG Mei-rong,LIU Ju*,ZHANG Xin-wei,ZHOU Yun-peng,CHEN Ye,WANG Yang,XU Li-feng
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文章历史 +

摘要

吡唑并嘧啶衍生物药理作用的广泛性,引起了人们的高度重视。此类化合物在合成上,有多种途径,包括以吡唑环为母环、以嘧啶环为母环和以其他原料合成等;在药理活性上,能高效杀菌、消炎、抗凝血和抗癌等。笔者以合成方法为主线,对吡唑并嘧啶衍生物的合成方法和药理活性研究进展进行了综述。

Abstract

Due to the extensive pharmacological effects, pyrazolopyrimidine derivatives have aroused great attention. There are a variety of ways in their synthesis, including using pyrazole ring, pyrimidine ring and other materials as parent ring. The compounds have strong bactericidal, anti-inflammatory, anti-cancer and anti-virus activities, etc. In this paper, the synthesis and pharmacological activities of pyrazolopyrimidine derivatives taking the synthesis as the main line are summarized.

关键词

吡唑并嘧啶衍生物 / 合成 / 药理活性

Key words

pyrazolopyrimidine derivative / synthesis / pharmacological activity

引用本文

导出引用
张美荣,刘举*,张新威,周云鹏,陈烨,王洋,徐利锋. 吡唑并嘧啶衍生物合成及其活性研究进展[J]. 中国药学杂志, 2015, 50(3): 194-200 https://doi.org/10.11669/cpj.2015.03.002
ZHANG Mei-rong,LIU Ju*,ZHANG Xin-wei,ZHOU Yun-peng,CHEN Ye,WANG Yang,XU Li-feng. Research Progress of Synthesis and Pharmacological Activity of Pyrazolo Pyrimidine Derivatives[J]. Chinese Pharmaceutical Journal, 2015, 50(3): 194-200 https://doi.org/10.11669/cpj.2015.03.002
中图分类号: R96   
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