摘要：

偏头痛与神经血管调控失衡、脑网络功能异常等因素相关，因临床表型异质性较大，诊断及分型仍以症状学为主，缺乏特异性，因此建立可重复、量化的客观影像学标志物是偏头痛研究和临床转化的关键方向。多模态MRI通过整合结构像、扩散像、静息态功能像及灌注成像，在同一框架下评估脑结构损伤、脑功能重塑与脑血流变化之间的关系，为阐明偏头痛发生机制、亚型差异和慢性化进程提供更系统的证据。本文围绕结构、功能、结构-功能耦合3个层面综述多模态MRI在偏头痛中的研究进展及其临床应用价值。

关键词: 偏头痛, 磁共振成像, 综述

Abstract:

Migraine is increasingly recognized as a disorder involving neurovascular dysregulation and large-scale brain network dysfunction. However, because of its substantial clinical heterogeneity, diagnosis and subtype classification still rely predominantly on symptom-based criteria, and specific biomarkers remain unavailable. The identification of objective, reproducible, and quantifiable imaging markers has become a major priority in both migraine research and clinical translation. By integrating structural MRI, diffusion MRI, resting-state fMRI, and perfusion imaging within a unified framework, multimodal MRI enables a comprehensive evaluation of the interplay among structural alterations, functional reorganization, and cerebral perfusion changes. This multimodal approach provides more robust evidence for elucidating the pathophysiological mechanisms of migraine, characterizing subtype-specific neuroimaging features, and clarifying processes related to chronification. In this review, we summarize recent advances and potential clinical applications of multimodal MRI in migraine from three perspectives: brain structure, brain function, and structure-function coupling.

Key words: Migraine, Magnetic resonance imaging, Review

中图分类号: 

• R741

• R445