摘要：

偏头痛与抑郁障碍在临床上常以共病形式存在，进一步增加二者的治疗难度。偏头痛与抑郁障碍存在双向相关，且互为危险因素，但具体机制尚不明确。偏头痛与抑郁障碍在病理生理学机制上存在重叠，涵盖脑区结构或功能改变、神经递质、神经肽及性激素代谢紊乱、遗传因素、应激、环境因素以及免疫炎症多方面的影响。偏头痛与抑郁障碍共病的治疗方式呈多样化，需针对二者共病的病理生理学机制进行个体化治疗，本文拟从流行病学、共同病理生理学机制和治疗进展等方面进行综述，以为临床诊断与治疗提供帮助。

关键词: 偏头痛, 抑郁, 共病现象, 流行病学, 病理学, 生理学, 治疗, 综述

Abstract:

Migraine and depressive disorder often present as comorbid conditions in clinical practice, which further complicates the treatment of both disorders. A bidirectional relationship exists between migraine and depressive disorder, with each acting as a risk factor for the other; however, the underlying mechanisms remain unclear. There is considerable overlap in the pathophysiological mechanisms of migraine and depressive disorder, involving alterations in brain region structure and function, disturbances in neurotransmitter, neuropeptide, and sex hormone levels, as well as genetic factors, stress, environmental influences, and immune-inflammatory processes. The treatment approaches for the comorbidity between migraine and depressive disorder is diverse, requiring individualized therapy tailored to the pathophysiological mechanisms underlying their coexistence. This article reviews the epidemiology, shared pathophysiological mechanisms, and therapeutic advances in migraine comorbid with depressive disorder, with the aim of informing clinical diagnosis and management.

Key words: Migraine, Depression, Comorbidity, Epidemiology, Pathology, Physiology, Therapy, Review

中图分类号: 

• R747.2

• R749.4