中国药学杂志
    
           首页  |  期刊介绍  |  编 委 会  |  投稿指南  |  期刊订阅  |  广告服务  |  会议信息  |  联系我们  | 
�й�ҩѧ��־ 2007, Vol. 42 Issue (24) :1881-1884    DOI:
���� ����Ŀ¼ | ����Ŀ¼ | ������� | �߼����� << | >>
����ɳ����������ҩ��ѧ�о�
����;������;������;���;������
1.ɽ����ʿ�׸������ҩ���޹�˾ ���� 250014;2.ɽ��ʡҽҩ��ҵ�о���ҩ�ﰲȫ���������� ���� 250033
ZHANG Qing1��CHENG Yan-ling2��BAI Ruo-wan1��SONG Hai-bo2��HE Yan-li1
1. Shandong B&L Freda Pharm. Co.��Ltd.��Jinan 250014��China��2.Drug Safety Evaluation Center of Shandong Institute of Pharmaceutical Industry��Jinan 250033��China

Download: PDF (0KB)   HTML (0KB)   Export: BibTeX or EndNote (RIS)      Supporting Info
ժҪ Ŀ���о�����ɳ�������������ε��ۺ����ɳ�ǵ�ҩ��ѧ�����������ɳ�ǵ���Һ���бȽϡ�������������������,���۵������ɳ����������60��L,���۵������ɳ�ǵ���Һ60��L,�ֱ��ڲ�ͬʱ��ȡ��Һ����ˮ�ͽ�Ĥ,����Һ-������(LC-MS)�ķ��������е�ҩ�ﺬ�����вⶨ�����ʵ����Ͷ����鵥�θ�ҩ��,��Һ��ҩ��������˥�ڷֱ�Ϊ195.3��80.7 min,AUC0��480�ֱ�Ϊ62 385��33 280��g��min��g-1;��ˮ��ʵ������������ҩ����Ũ�ȷֱ�Ϊ1.05��0.62mg��L-1,���ʱ���Ϊ60 min,AUC0��360�ֱ�Ϊ111.7��66.1 mg��min��L-1;��Ĥ��ʵ������������AUC0��480�ֱ�Ϊ3 435.5��1 688.4��g��min��g-1������ʵ��ҩ�����ҩ��ҩ��ѧ����������������,����ɳ������������ҩ��ҩ������Һ����ˮ�ͽ�Ĥ�о��нϸߵ�ҩ��Ũ������ά�ֽϳ���ʱ��,�ϼ���ɳ�ǵ���Һ�������ö�������ߡ�
Service
�ѱ����Ƽ�������
�����ҵ����
�������ù�����
Email Alert
RSS
�����������
�ؼ����� ����ɳ��   ��������     
Abstract�� OBJECTIVE To compare the pharmacokinetics and bioavailability of gatifloxacin ophthalmic gel with gatifloxacin eye drops by topical application.METHODS New Zealand rabbits' left eyes were topically applied 60 ��L of gatifloxacin ophthalmic gel,the right eyes were topically applied 60 ��L of gatifloxacin eye drops.Tears,aqueous humors and corneas were sampled at different intervals after drug instillation,and the drug levels were assayed by liquid chromatograph/mass spectrometer(LC-MS).RESULTS The half-lives of elimination in the tears were 195.3 and 80.7 min,and the AUC0��480 of the drug levels in the tears were 62 385 and 33 280 ��g��min��g-1 for the test group and the reference group respectively.The peak levels of drug in aqueous humors were 1.05 and 0.62 mg��L-1,and the AUC0��360 of the drug levels in the aqueous humors were 111.7 and 66.1 mg��min��L-1 respectively.The AUC0��480 of the drug levels in the corneas were 3 435.5 and 1 688.4 ��g��min��g-1 respectively.CONCLUSION The bioavailability of gatifloxacin ophthalmic gel was increased significantly,and its action time was obviously increased compared with gatifloxacin eye drops.
Keywords�� gatifloxacin,   ophthalmic gel,   pharmacokinetics      
�ո�����: 2007-07-25;
���ñ���:   
.����ɳ����������ҩ��ѧ�о�[J]  �й�ҩѧ��־, 2007,V42(24): 1881-1884
.Pharmacokinetics of Gatifloxacin Ophthalmic Gel in Ocular Delivery [J]  Chinese Pharmaceutical Journal, 2007,V42(24): 1881-1884
��
û�б��IJο�����
Copyright 2010 by �й�ҩѧ��־