Abstract：The plants of the genus Ophiorrhiza, belonging to the family Rubiaceae, are widely distributed all over the world. Since ancient times, these plants has been recorded in many medical literatures. They were regarded as the medicines for promoting blood circulation, removing blood stasis, eliminating phlegm and relieving cough. Literatures revealed that the Ophiorrhiza plants offer an enormous constituents with novel structures and significant biological activities. Therefore, more and more scientists devoted themselves to the research of this medicinal plant resource. Currently, diverse chemical substances have been isolated from thirty-one species of the genus Ophiorrhiza, including sixty-two alkaloids, twenty-one terpenoids, twenty-one anthraquinones, six steroids, two flavonoids, one coumarin.In addition, they exhibit a variety of biological activities, such as anti-tumor, immunosuppressive, antibacterial, antiviral, antiinflammatory, antidiarrhea, gastric mucosal protection and insect repellent. In this review, the research from 1976 to July 2021 on the chemical constituents and pharmacological activities of the genus Ophiorrhiza are summarized, especially for the typical compounds and their structural characteristics including the absolute configurations, which could provide a scientific reference for the follow-up research and development of these medicinal plant resources in future.
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ZHONG Lin-jing, LIANG Lin-fu, CHEN Jun-kun, BU Qing, XU Meng-juan. Research Progress on Chemical Constituents and Pharmacological Activities from the Genus Ophiorrhiza. Chinese Pharmaceutical Journal, 2022, 57(15): 1221-1231.
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