Advances in Study on Novel Anti-Tumor Drugs-Induced Cardiotoxicity and Molecular Mechanisms
HOU Huan1,2, LIN Chen1,2, ZHANG Min1,2, JIANG Zhen-wei2, CHEN Rong1*
1. Department of Pharmacology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China; 2. School of Pharmacy, Soochow University, Suzhou 215123, China
Abstract：Cancer has become the world's largest cause of human death, for which the morbidity and mortality are rising. Based on the current treatment regimens of malignant tumors, traditional chemotherapy drugs can not fully meet the clinical needs. Novel anti-tumor drugs targeting specific sites, to a certain extent, reduce toxic and side effects, and significantly improve the mortality and poor prognosis of cancer patients. However, cardiovascular toxicity caused by such drugs, especially cardiotoxicity, has become an important factor affecting the survival and prognosis of patients, thus attracting more and more scholars' attention. This review will highlight recent research of cardiotoxicity caused by novel antitumor drugs and the possible molecular mechanisms.
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