Abstract：Quercetin is a flavonoid compound, which is widely present in various vegetables, fruits and Chinese herbal medicines that people eat daily. Quercetin is a natural antioxidant and has a wide range of pharmacological activities. It can regulate the intracellular and extracellular signaling pathways related to the progression of many diseases, possessing anti-inflammatory, anti-viral, anti-cancer activities, thus can be used to prevent and treat cardiovascular and cerebrovascular diseases. Its structural characteristics and low bioavailability has limited its clinical application. Quercetin has been modified into derivatives through structural optimization with excellent performance, good solubility, high bioavailability, stable metabolism, low toxic and side effects, and significant biological activity. This article reviews the quercetin derivatives synthesized using quercetin as the lead compound in the past decade, and highlights the pharmacological effects of these derivatives, such as anti-inflammatory, effect hypoglycemic, anti-cancer, anti-Alzheimer's disease, anti-malaria, etc., to lay the foundation for the development and utilization of natural compounds.
李阳杰, 姜亚玲, 刘秋伟, 翟广玉. 槲皮素衍生物的生物活性研究进展[J]. 中国药学杂志, 2021, 56(3): 175-180.
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