Progress in Study of Platinum Antitumor Compounds Modified by Glycosylation
ZHANG Qiang1, LI Shao-qing1, LIU Wei1, SHAO Jia2*, TIAN Jin-lei1*, WEI Jin-xia3
1. College of Chemistry, Nankai University, Tianjin 300071, China; 2. Department of Pharmacy, Tianjin First Central Hospital, Tianjin 300192, China; 3. Department of Military Pharmacy, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Abstract：Platinum drugs are one of the key therapeutic drugs for many malignant tumors, but traditional platinum drugs have poor tumor targeting effect and obvious side effects, so it is necessary to improve the targeting of platinum drugs for increasing their antitumor activity. Sugars and their derivatives are indispensable substances for the transmission of information between cells. Tumor cells can specifically recognize, and effectively absorb drug molecules containing specific sugar through Warburg effect. The selectivity of traditional platinum drugs to tumor cells can be effectively improved by functional glycosylation. In addition, with reasonable glycosylation, there is significant improvement in the targeting effect and water solubility of platinum drugs, with low collateral effects. Therefore, the design of glycosyl platinum compounds is one of the hotspots in the field of anticancer platinum drugs. Based on the above background, the research progress in glycosylated platinum compounds in the field of antitumor treatment is reviewed.
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2020, Vol. 55 
