Abstract：OBJECTIVE To investigate the taste-masking effect of montelukast sodium orally disintegrating tablets using electronic tongue technology and human sensory evaluation and determine the optimum formulation. METHODS Orally disintegrating tablets were prepared with five different concentrations of flavoring agents or without flavoring agent.The tastes of those tablets were determined by electronic tongue, and principal component analysis and linear discriminant analysis were used to evaluate differences of different formulations. The taste-masking effect of the tablets was investigated combined with electronic tongue analysis and sensory evaluation of subjects. RESULTS The taste of orally disintegrating tablet was the best when the total amount of flavoring agent was 1.6 mg, and the ratio of sweetening agent to aromatic agent was 5∶3. CONCLUSION The combination of electronic tongue and human sensory assess can evaluate the taste-masking effect of orally disintegrating tablets and provide the basis for determining the optimum formulation.
何朝星, 杜宇坤, 杨鑫, 何函星, 王晓晖, 杜青, 曹德英. 应用电子舌和感官评定方法考察孟鲁司特钠口崩片的掩味效果[J]. 中国药学杂志, 2020, 55(16): 1354-1357.
HE Chao-xing, DU Yu-kun, YANG Xin, HE Han-xing, WANG Xiao-hui, DU Qing, CAO De-ying. Taste-Masking Effect of Montelukast Sodium Orally Disintegrating Tablets Using Electronic Tongue Analysis and Human Sensory Evaluation Method. Chinese Pharmaceutical Journal, 2020, 55(16): 1354-1357.
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2020, Vol. 55 
