Abstract：Nonalcoholic fatty liver disease (NAFLD), a clinical metabolic stress-induced liver injury, is expressed as a feature of intrahepatic cell steatosis and excessive fatty deposition. NAFLD is a rising cause of common chronic liver disease worldwide. However, due to the lack of idealized NAFLD experimental models, the pathogenesis of NAFLD remains to be elucidated and consequently the research and development of therapeutic drugs against NAFLD has been making a relatively slow progress. Therefore, the establishment of cell and animal models is of great significance for exploring its pathogenesis and screening relevant experimental drugs. In this paper, the experimental models involved in NAFLD are reviewed and its advantages and disadvantages are evaluated further in vitro and in vivo, which provides a sufficient theoretical basis and model selection for the investigation and development of innovative drugs against NAFLD.
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