Abstract：OBJECTIVE To establish evaluation standard for clinical use of inhaled budesonide suspension (referred as “budesonide” below) and apply in clinical practice. METHODS Primary literatures of budesonide inhalation were retrieved from online databases including PubMed, EMbase, Cochrane Library, CNKI, CBM, Wanfang, GIN and NGC. Classification strategy and descriptive analysis were used to screen and summarize the evidence of each literature. The evidence quality of guidelines and consensus were assessed by AGREE Ⅱ, and that of the systematic reviews were assessed by OQAQ. The evidence-based standard for evaluation of budesonide prescription was established. Followed this criteria, a sampling review of budesonide cases was conducted. RESULTS A total of 2 396 articles were initially retrieved and 26 literatures including 11 off-label indications met the inclusion criteria. Among them, COPD patients with acute exacerbation or high risk of relapses, acute croup, bronchiectasis with airflow obstruction or hyper responsiveness of the airway were supported by high-quality evidence. The perioperative period use of budesonide was limited to general anesthesia via endotracheal intubation, thoracic surgery or throat surgery, and patients should have high risk factors. Acute inflammation of the throat was only considered for patients who were with obvious airway obstruction and diagnosed as acute epiglottitis, acute laryngitis, acute tonsillitis and acute pharyngitis. The sampling review from a 3A hospital was showed that, among the 240 cases, 95 cases(rate 39.58%) was irrational use of budesonide, the most common misuse were perioperative period and pulmonary infection. CONCLUSION The prescription evaluation standard of inhaled budesonide is established by evidence-based evaluation, which proves as practical and operable, and of great significance to standardize the clinical use of budesonide.
曾钰, 刘宇, 宋捷, 邱峰, 赵青青, 欧倩怡. 基于循证评价建立吸入用布地奈德混悬液临床应用标准[J]. 中国药学杂志, 2019, 54(16): 1343-1348.
ZENG Yu, LIU Yu, SONG Jie, QIU Feng, ZHAO Qing-qing, OU Qian-yi. Establishment of Evaluation Standard for Clinical Use of Inhaled Budesonide Suspension Based on Evidence-based Review. Chinese Pharmaceutical Journal, 2019, 54(16): 1343-1348.
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2019, Vol. 54 
