Abstract��OBJECTIVE To explore the potential mechanism of Erchen decoction for the prevention and treatment of obesity.METHODS With the big data of traditional Chinese medicine as a means of information technology,based on the traditional Chinese medicine prescription database, Chinese herbal medicine database, Chinese medicine component database and disease symptom target database of internet-based computation platform for integrative pharmacology of traditional Chinese medicine, we explore the possible mechanism of Erchen decoction in prevention and treatment of obesity. Establishing a visual multi-level network of Erchen decoction-Chinese Herbs-Ingredients-Critical Targets and Pathways to explore the mechanism of Erchen decoction. RESULTS The one hundred and five targets of 305 compounds of Ershen decoction were screened out by platform to be correlated with key targets of obesity. The targets such as HADHA, HADH and NSDHL are involved in the regulation of phosphatidylcholine biosynthetic process, positive regulation of transcription from RNA polymerase �� promoter in response to endoplasmic reticulum stress, etc. CONCLUTION Through the platform that the mechanism of Erchen decoction in preventing and treating of obesity may be related to its role in glycerophospholipid metabolism, lipid metabolism, nervous system, etc were founded. in order to clarify its foundation for the molecular mechanism of obesity, and it is of great significance to dig deeper and develop the traditional Chinese medicine prescription Erchen decoction.
�첩Ƚ, ս����. ������ҩ����ҩ��ѧƽ̨̽�����������η��ֵ����ʻ��������û���[J]. �й�ҩѧ��־, 2019, 54(7): 536-541.
ZHUBo-ran, ZHANLi-bin. Based on Internet-based Computation Platform for Integrative Pharmacology of Traditional Chinese Medicine,Exploring the Mechanism of Erchen Decoction in Prevention and Treatment of Obesity. Chinese Pharmaceutical Journal, 2019, 54(7): 536-541.
CHEN X, HUANG W, DENG J, et al. Recent clinical research of traditional Chinese medicine for simple obesity[J]. Chin Arch Tradit Chin Med(�л���ҽҩѧ��), 2017,35(6):1454-1458.
GBD Obesity Collaborators. Health effects of overweight and obesity in 195 countries over 25 years[J]. New Engl J Med, 2017, 377(1):13-27.
YANG S Q, CHEN H G, DENG W, et al. Effects of blood mansion stasis-expelling decoction combined with two matured substances decoction on adipocytokines in obese rats[J]. J Beijing Univ Tradit Chin Med (������ҽҩ��ѧѧ��), 2015, 38(2):104-110.
DING S S, KANG J, ZHANG L Y, et al. Effects of Erchen Decoction on the expressions of Cav-1 and PI3K/AKT in mice model of lipid metabolism disorder[J]. China J Tradit Chin Med Pharm (�л���ҽҩ��־), 2017,32(1):242-244.
WU T Y, LIN S, ZHENG L. Influence of Erchen decoction on high-fat-diet Wistar rats�� weight and lipid metabolism[J]. J Zhejiang Chin Med Univ (�㽭��ҽҩ��ѧѧ��), 2012, 36(11):1218-1238.
XU H Y, LIU Z M, FU Y. Exploiture and application of an internet-based computation platform for integrative pharmacology of traditional Chinese medicine[J]. China J Chin Mater Med (�й���ҩ��־), 2017, 42(18):3633-3688.
CHENG X L, CHANG Y, WANG L J, et al. Serum levels of betaine and choline and their correlation with anthropometric indices and life style related factors in people undergo physical examination[J]. Acta Nutr Sin (Ӫ��ѧ��), 2015, 37(3):239-244.
LI B, LI W, WANG T. Research progress of regulation and mechanism of choline on lipid metabolism[J]. J Chin Cereals Oils Assoc, 2016, 31(1):142-146.
HUANG S, PAN Y W, LAN H, et al. Pachymic acid advances in pharmacology[J]. Chin Tradit Pat Med (�г�ҩ), 2015, 37(12):2719-2721.
PENG C, YU S L, ZHANG J, et al. Simultaneous determination of four kinds of triterpene acids in Poria cocos by HPLC[J]. J Chin Med Mater (��ҩ��), 2017, 40(7):1643-1646.
ZHENG C Y. Experimental research of the anti-diabetic pachymaran role[J]. Nat Med Front China(�й�ҽ��ǰ��), 2010, 5(14):12-13.
ZHANG W N. Progress on pharmacodynamic material basic of traditional Chinese medicine[J]. Chin Pharm J(�й�ҩѧ��־), 2018, 53(10):761-764.
LI P L, SU W W. Recent progress in applying network pharmacology to research of Chinese materia medica[J]. Chin Tradit Herb Drugs (�в�ҩ), 2016, 47(16):2938-2942.
YUAN W F, TU M Y, CHEN C, et al. Network pharmacology study of compound Danshen Dropping pill based on molecular docking and recognition of biological network function modules[J]. China J Chin Mater Med(�й���ҩ��־), 2017, 52(9):743-749.
PAN B Q, ZHEN Q P, LIU J F, et al. Analysis on medication rule in herbal prescriptions for simple obesity[J]. Guid J Tradit Chin Med Pharmacol(��ҽҩ����), 2017,23(12):49-51.
YAO R, CHEN M J. Erchen Decoction for the treatment of obesity caused by antipsychotics[J]. Neural Injury and Functional Reconstruction(�������빦���ؽ�), 2014, 9(4):355-356.
HE T, ZHOU B, LEI J, et al. Erchen Decoction combined with acupuncture at Fenglong, Zhongwan and other points to treat phlegm and internal resistance type vertigo[J]. Hubei J Tradit Chin Med(������ҽҩ��־), 2013, 35(10):56-56.
SHI L, YANG P, GUO S, et al. Effect of Erchen Tang on CYP2E1 and mitochondrial energy metabolism in nonalcoholic fatty liver diseases[J]. China Pharm(�й�ҩʦ), 2017, 20(2):205-207.
JIANG Z Q. Clinical observation of modified Erchen decoction in treating cough after cold[J]. Clin J Chin Med(��ҽ�ٴ��о�), 2017, 9(6):21-23.
PÉREZSCHINDLER J, KANHERE A, EDWARDS L, et al. Exercise and high-fat feeding remodel transcript-metabolite interactive networks in mouse skeletal muscle[J]. Sci Rep, 2017, 7(1):1-11.
WYLER S C, LORD C C, LEE S, et al. Serotonergic control of metabolic homeostasis[J]. Frontiers in Cellular Neuroscience, 2017, 11(277):1-9.
BHAT Z, MORTON J D, MASON S, et al. Obesity and neurological disorders:dietary perspective of a global menace[J]. Crit Rev Food Sci Nutr, 2017, 57(1):1-17.
ILENIA M, DANIELE T, MICHELE M, et al. Obesity and metabolic syndrome affects the cholinergic transmission and cognitive functions[J]. Cns & Neurological Disorders Drug Targets, 2017, 16(6):664-676.
ZHANG S, WANG B, SHI J, et al. Network-based association study of obesity and type 2 diabetes with gene expression profiles[J]. Biomed Res Int, 2015, 2015(5):1-9.