Based on Internet-based Computation Platform for Integrative Pharmacology of Traditional Chinese Medicine,Exploring the Mechanism of Erchen Decoction in Prevention and Treatment of Obesity
ZHUBo-ran, ZHANLi-bin*
Basic Medical College, Modern Research Laboratory of Spleen Visceral Manifestations Theory, Nanjing University of Chinese Medicine, Nanjing 210023, China
Abstract��OBJECTIVE To explore the potential mechanism of Erchen decoction for the prevention and treatment of obesity.METHODS With the big data of traditional Chinese medicine as a means of information technology,based on the traditional Chinese medicine prescription database, Chinese herbal medicine database, Chinese medicine component database and disease symptom target database of internet-based computation platform for integrative pharmacology of traditional Chinese medicine, we explore the possible mechanism of Erchen decoction in prevention and treatment of obesity. Establishing a visual multi-level network of Erchen decoction-Chinese Herbs-Ingredients-Critical Targets and Pathways to explore the mechanism of Erchen decoction. RESULTS The one hundred and five targets of 305 compounds of Ershen decoction were screened out by platform to be correlated with key targets of obesity. The targets such as HADHA, HADH and NSDHL are involved in the regulation of phosphatidylcholine biosynthetic process, positive regulation of transcription from RNA polymerase �� promoter in response to endoplasmic reticulum stress, etc. CONCLUTION Through the platform that the mechanism of Erchen decoction in preventing and treating of obesity may be related to its role in glycerophospholipid metabolism, lipid metabolism, nervous system, etc were founded. in order to clarify its foundation for the molecular mechanism of obesity, and it is of great significance to dig deeper and develop the traditional Chinese medicine prescription Erchen decoction.
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ZHUBo-ran, ZHANLi-bin. Based on Internet-based Computation Platform for Integrative Pharmacology of Traditional Chinese Medicine,Exploring the Mechanism of Erchen Decoction in Prevention and Treatment of Obesity. Chinese Pharmaceutical Journal, 2019, 54(7): 536-541.
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2019, Vol. 54 
