Chemical Constituents of Antitumor Active Fractions from Parnassia palustris
XIN Ying1, DA-LA-HU2, HONG Yan1, LI Gui-hua1, CHUN Ling1, WEN Hua1
1. College of Traditional Mongolian Medicine, Inner Mongolia University for Nationalities, Tongliao 028000, China;
2. Department of Pharmceutics of Kulun's Mongolia Hospital, Kulun 028200, China
OBJECTIVE To study the chemical constituents of the antitumor active fractions from Parnassia palustris. METHODS The chemical constituents of dichloromethane and ethyl acetate extracts from Artemisia integrifolia L were isolated by kinds of chromatography. Their structures were identified by NMR data analysis. RESULTS Five compounds, namely celahin B(1), mussaenin A (2), gardendiol (3), isoboonein (4), 4-epi-alyxialactone (5) from the dichloromethane extract and six compounds, namely quercetin (6), kaempferol (7), gallic acid (8), chlorogenic acid (9), hyperosid (10), and kaempferol-3-O-beta-rutinoside (11) from the ethyl acetate extract were obtained. CONCLUSION Compounds 1-5, 7, 9, and 10 are isolated from this plant for the first time.
��ӱ,������,����,���,����,�Ļ�. ÷���ݿ��������Բ�λ��ѧ�ɷ��о�[J]. �й�ҩѧ��־, 2019, 54(4): 264-267.
XIN Ying, DA-LA-HU, HONG Yan, LI Gui-hua, CHUN Ling, WEN Hua. Chemical Constituents of Antitumor Active Fractions from Parnassia palustris. Chinese Pharmaceutical Journal, 2019, 54(4): 264-267.
Department of health of the Inner Mongolia Autonomous Region. Mongolian Medicine Standard in Inner Mongolia (���ɹ���ҩ�ı�) . Huhehaote: Inner Mongolia Science and Technology Press, 1987:173-174.
[2]
ZHAN B L D E J. Mengyaozhengdian (��ҩ����) . Huhehaote: Inner Mongolia Peoples Publishing House,1988:161-164.
[3]
BAI Q Y. Encyclopedia of Chinese Medicine��Mongolian Medicine (�й�ҽѧ�ٿ�ȫ�顤��ҽѧ) . Huhehaote: Inner Mongolia Science and Technology Press, 1986: 532-533.
WANG Q H, WU R J, QI G Q, et al. Chemical constituents of Artemisa sacrorum Ledeb . Chin Pharm J(�й�ҩѧ��־), 2015, 50 (16):1380-1383.
[6]
HONG Y, DA L H, XIN Y. Experimental study on inhibiting proliferation of tumor cell of ethanol extract of Mongolian medicine of Parnassia palustris Linn . J Inner Mongol Univ(Nat Sci) (���ɹ������ѧѧ��), 2016, 26(2):43-47.
[7]
XIN Y, DA L H, HONG Y. Experimental study on the antitumor activity of ethanol extracts of Mongolian medicine Parnassia palustris Linn . J North Pharm (����ҩѧ), 2016, 13(9):128-129.
[8]
CHUN L, DA L H, WEN H, et al. Inhibitory effect of different extracts of Mongolian medicine Parnassia palustris on proliferation of tumor cells in vitro . World Latest Med Inf(��������ҽѧ��Ϣ��ժ),2018,18(16):21-22,27.
[9]
CAI Y. Determination of kaempferol, quercetin in wideword parnassia herb by HPLC . Qilu Pharm Aff (��³ҩ��), 2011, 30(6):322-325.
[10]
WANG R, WU M J, ZHANG H Y, et al. An NMR study on celahin B . Henan Sci (���Ͽ�ѧ), 2012, 30 (5):560-563.
[11]
ZHAO W M, YANG G Y, XU R S, et al. Three monoterpenes from Mussaenda pubescens . Phytochemistry, 1996, 41 (6):1553-1555.
[12]
ZHAO W M, XU J P, QIN G W. Two monoterpenes from fruits of Gardenia jasminoides . Phytochemistry, 1994, 37 (4):1079-1082.
[13]
BIANCO A, LUCA A D, MAZZEI R A, et al. Iridoids of Rauwolfia grandiflora . Phytochemistry, 1994, 35(6):1485-1487.
[14]
TOPCU G, CHE C T, CORDELL G A, et al. Iridolactones from Alyxia reinwardti . Phytochemistry, 1990, 29(10): 3197-3199.
[15]
RUSHDI A I, RITTER G, GRIMALT J O, et al. Hydrous pyrolysis of cholesterol under various conditions . Org Geochem, 2003, 34 (6):799-812.
[16]
NI F Y, CHEN Z, XU Q M, et al. Chemical constituents from Rhodiola sachalinensis. Chin Tradit Herb Drugs (�в�ҩ), 2013, 44 (7):798-802.
[17]
REN F X, ZHANG A J, ZHAO Y M. Study on the chemical constituents of Pyrola calliantha H. Andres. Nat Prod Res Dev (��Ȼ�����о��뿪��), 2010, 22 (1):54-57.
[18]
CHEN R, LUO Y G, HU X Y, et al. Chemical study on Alus nepalensis. Nat Prod Res Dev (��Ȼ�����о��뿪��), 2008, 4 (6):578-581.
[19]
SUN C L, SHANG X L, ZHOU J F, et al. Study on chemical constituents of Cinnamomum camphora leaves. Nat Prod Res Dev (��Ȼ�����о��뿪��), 2014, 11 (8):1793-1796.
[20]
GRANADO-SERRANO A B, MART��N M A, BRAVO L, et al. Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2). J Nutr, 2006, 136(11):2715-2721.
[21]
KANG G Y, LEE E R, KIM J H, et al. Downregulation of PLK-1 expression in kaempferol-induced apoptosis of MCF-7 cells . Eur J Pharmacol, 2009, 611(1-3):17-21.
[22]
LO C, LAI T Y, YANG J S, et al. Gallic acid inhibits the migtation and invasion of A375.S2 human melanoma cells through the inhibition of matrix metalloproteinase-2 and ras. Melanoma Res, 2011, 21(4):267-273.
[23]
MATSUNAGA K, KATAYAMA M, SAKATA K, et al. Inhibitory effects of chlorogenic acid on azoxymethane-induced colon carcinogenesis in male F344 rats . Asian Pac J Cancer Prev, 2002, 3(2):163-166.
[24]
YAN S T, WANG X Q, LIAO G H. Advances in pharmacological effects of hyperoside . Chin J Mod Appl Pharm(�й��ִ�Ӧ��ҩѧ), 2018, 35 (6):947-951.
2019, Vol. 54 
