Research Progress in Synaptic Plasticity Impairment of Diabetic Encephalopathy
YIN Hua-jing1, WANG Wei-ping2, WANG Xiao-liang2*
1. Center for Drug Evaluation, China Food and Drug Adminstration, Beijing 100022, China; 2. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Abstract��Previous studies demonstrate that diabetes mellitus induces cognitive impairment,leading to diabetic encephalopathy(DE), which is closely related with hippocampal synaptic plasticity impairment,including synaptic structural and functional damage. Structural damage mainly embodied in the synapse degeneration.Functional damage mainly reflects in the LTP damage, including the composition variation and functional lesions of N-methyl-D-aspartate receptors(NMDARs), ��-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) and patassium channels.Abnormal synaptic plasticity may be critical in the pathogenesis of diabetic encephalopathy. In this review, we summarized the relationship between DE and synaptic plasticity impairment.
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YIN Hua-jing, WANG Wei-ping, WANG Xiao-liang. Research Progress in Synaptic Plasticity Impairment of Diabetic Encephalopathy. Chinese Pharmaceutical Journal, 2018, 53(21): 1805-1809.
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