Effects of p-Coumaric Acid on Preventing Acute Hypoxia-Induced Pulmonary Edema Mice
CHU Bing-quan1,2, LI Yun-hong1, LI Jiao-jie3, ZHANG Ying1*
1. College of Biosystems Engineering and Food Science, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang Engineering Center for Food Technology and Equipment, Zhejiang University, Hangzhou 310058, China; 2. School of Biological and Chemical Engineering/School of Light Industry, Zhejiang University of Science and Technology, Zhejiang Provincial Key Laboratory of Chemical and Biological Processing Technology of Farm Products, Zhejiang Provincial Collaborative Innovation Center of Agricultural Biological Resources Biochemical Manufacturing, Hangzhou 310023, China; 3. Aviation Medicine Training Center of Hangzhou, Hangzhou 310007, China
Abstract��OBJECTIVE To study the preventing effects of p-coumaric acid(p-CA) on acute hypoxia-induced pulmonary edema by mice experiments. METHODS Acute-hypoxia model was established using a normobaric hypoxia chamber in vivo. Salidroside was set as a positive control drug. And the test period was 7 d using a method of intragastric administration. The measurements including pulmonary water content, HE staining, inflammatory factors, anti-oxidative indexes and Na+, K+-ATPase were performed to determine the efficacies and mechanisms of p-CA on preventive against acute hypoxia-induced pulmonary edema. RESULTS As compared with the normal group, pulmonary water contents increased significantly by 3.56% in the mice treated with acute hypoxia (9.5% O2) for 6 h (control group) (P<0.01), and administration with p-CA (25, 100 mg��kg-1��d-1) for 7 d could significantly reduce this index (P<0.05), which was as effective as the positive group. The action mechanisms of p-CA could be due to its abilities of improving the activity of Na+, K+-ATPase, enhancing antioxidant capacity (SOD��, CAT�� and MDA��) and inhibiting inflammatory factors (IL-1�� and IL-6). CONCLUSIONp-CA has greater preventive effects on acute hypoxia-induced pulmonary edema in mice.
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2018, Vol. 53 
