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Recent Progress in Understanding the Mechanism of Neuroprotective Effect of Pinocembrin
WANG Yu-min1a, GE Yong-li2, ZHAO Li-nan1b, ZHAO Wei-li1c, DU Guan-hua3*, WANG Hong-quan1c,3*
1a. Department of Oncology; 1b. Central Lab, 1c. Department of Neurology, Affiliated Hospital, Chifeng Medical College, Chifeng University, Chifeng 024005, China; 2. Department of Oncology, Inner Mongolia People��s Hospital, Huhehot 010017, China; 3. Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China
Abstract��Pinocembrin (5, 7-dihydroxyflavanone), a flavanone, is a natural flavonoid compound extracted from honey, propolis, ginger roots, wild marjoram, and other plants. In preclinical studies, it has shown to have neuroprotective effects as well as the ability to reduce reactive oxygen species, protect the blood-brain barrier, modulate mitochondrial function, and regulate apoptosis. Considering these a variety of pharmacological activities, pinocembrin has potential as a drug to treat ischemic stroke and neurodegenerative disease. Its pharmacologic characteristics are summarized and mechanistic details relating preclinical studies are discusses.
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WANG Yu-min, GE Yong-li, ZHAO Li-nan, ZHAO Wei-li, DU Guan-hua, WANG Hong-quan. Recent Progress in Understanding the Mechanism of Neuroprotective Effect of Pinocembrin. Chinese Pharmaceutical Journal, 2018, 53(4): 245-248.
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2018, Vol. 53 
