Application and Development of Volunteer Sensory Test in Drug Taste Evaluation
LI Pan1, HAN Xue1, LIN Jun-zhi2*, JIANG Hong1, YANG Ming3, ZHANG Ding-kun1*, HAN Li1
1. Pharmacy College, Development and Utilization of Chinese Medicine Resources in Sichuan Province Key Laboratory Breeding Base of Co-founded by Sichuan Province and MOST, Chengdu University of Traditional Chinese Medicine; Key Laboratory of Systematic Research, Chengdu 611137, China;
2. Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China;
3. Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
Taste is not only an important factor which could impact drug availability and compliance of patient, but also the study content which needs to be investigated in the formulation of pharmaceutical preparations. In order to mask the bad taste of drugs, taste evaluation is increasingly important. With the development of science, the most widely used human volunteer test METHODS which could reflect the true sense of human volunteer continue being improved. Furthermore, the accuracy of the RESULTS is continually increasing. This paper summarized the current eight kinds of human evaluation METHODS in the world, and introduced the principle of experiment, training, scoring process and data processing of volunteeers, to provide new ideas for the taste evaluation of drugs and promote the development of the taste-masking technology and related theoretical basis.
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LI Pan, HAN Xue, LIN Jun-zhi, JIANG Hong, YANG Ming, ZHANG Ding-kun, HAN Li. Application and Development of Volunteer Sensory Test in Drug Taste Evaluation. Chinese Pharmaceutical Journal, 2017, 52(22): 1971-1975.
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2017, Vol. 52 
