Research Progress of Nebulized Heparin for Acute Lung Injury
HU Bin1,2, CHEN Gui-liang3*, WANG Hao2
1. School of Pharmacy, Fudan University, Shanghai 201203, China; 2. Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 201203, China; 3. Shanghai Institute for Food and Drug Control, Shanghai 201203, China
Abstract��It is widely recognized that alveolar fibrin deposition is a hallmark of acute lung injury. The inhaled anticoagulation regimens are employed to manage acute lung injury with the goal of improving lung function by decreasing airways fibrin deposition and obstruction.Inhalation administration may improve local biological availability and efficacy and lower the risk of systemic bleeding complications. Heparin is the most widely used anticoagulant in clinic. The author performed a systematic review of international preclinical studies and clinical trials of nebulized heparin for acute lung injury induced by smoke inhalation, severe infection and mechanical ventilation in animals and humans. It was demonstrated that nebulized heparin is a very prospective regimen in the treatment of acute lung injury.
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HU Bin, CHEN Gui-liang, WANG Hao. Research Progress of Nebulized Heparin for Acute Lung Injury. Chinese Pharmaceutical Journal, 2017, 52(4): 258-262.
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2017, Vol. 52 
