中国药学杂志
    
           首页  |  期刊介绍  |  编 委 会  |  投稿指南  |  期刊订阅  |  广告服务  |  会议信息  |  联系我们  | 
�й�ҩѧ��־ 2014, Vol. 49 Issue (6) :509-511    DOI: 10.11669/cpj.2014.06.018
ҩ�����ٴ� ����Ŀ¼ | ����Ŀ¼ | ������� | �߼����� << | >>
Ԥע����˳������臨Է�̫���շ����Ե�Ӱ��
���һ�, ���主, ����ƽ, ����, ��μ��, ¥��֥
�㽭����������ҽԺ, �㽭 ���� 312000
CHEN Zhong-hua, ZHOU Qi-fu, CHEN Nian-ping, CHEN Lei, YU Wei-sheng, LOU Jing-zhi
Shaoxing People��s Hospital of Zhejiang University, Shaoxing 312000, China

Download: PDF (2427KB)   HTML (1KB)   Export: BibTeX or EndNote (RIS)      Supporting Info
ժҪ Ŀ�� �۲������յ�ǰ����Ԥע����˳������臨Է�̫���շ�����(fentanyl-induced cough, FIC)������Ч�������� 200�����������Ϊ2��, ������(����)����ע��������ˮ1 mL;����˳�������Ԥ������(����)ע�䱽��˳�������0.01 mg��kg-1, ��������������о���ע��;�������5 min����ע���̫��4 ��g��kg-1, ע��ʱ��2 s����¼���黼�߿��Է����Ĵ����ͳ���ʱ��, �����ݿ��Է��������������س̶ȷּ�����ע��������ˮ�򱽻�˳�������ʱ��ע���̫��ʱ��ע���1��2 min�ֱ��¼Ѫѹ�����ʡ�����������Ѫ�����Ͷȼ�ҩ�ﲻ����Ӧ����� ���黼���Ա𹹳ɲ�����ͳ��ѧ����(P��0.05)������Ƚ�, �����̫���շ����Եķ�����(19.0%, 19/100)���Ե��ڢ���(41.0%, 41/100)(P��0.05);�����̫���շ��жȺ��ضȿ��Ի���Ϊ31.6%(6/19), �������ڢ����56.1%(23/41)(P��0.05);���Գ���ʱ���Ѫ������ѧ�����Ƚ����������ͳ��ѧ���塣���� ����˳�������Ԥ��������Ч���ͷ�̫���շ����Եķ����ʺ�ǿ�ȡ�
Service
�ѱ����Ƽ�������
�����ҵ����
�������ù�����
Email Alert
RSS
�����������
���һ�
���主
����ƽ
����
���
¥��֥
�ؼ����� ��̫��   ����   ����˳�������   Ԥע��     
Abstract�� OBJECTIVE To observe the effect of intravenous cisatracurium besilate pretreatment on fentanyl-induced cough (FIC). METHODS Totally 200 American Society of Anesthesiologists class ��-�� patients, aged 20-60 years within normal weight, scheduled for elective surgery, were randomly assigned to receive intravenous cisatracurium besilate 0.01 mg��kg-1(group ��) or normal saline (group ��) 5 min prior to the administration of fentanyl 4 ��g��kg-1 in a randomized and double-blind fashion. Any episode of cough was classified as coughing, and graded as mild (1-2), moderate(3-4), or severe (5 or more). We recorded the timing and severity of cough and monitored the vital signs and discomforts such as dizziness, tinnitus, nausea/vomiting, apnea and dysrhythmia. RESULTS The gender distribution showed no significant difference between two groups. The incidence of cough was 19.0%(19/100)in group �� and 41%(41/100)in group I(P��0.05).The incidence of moderate and severe cough was significantly higher in the group ��(56.1%, 23/41)than in group ��(31.6%, 6/19)(P��0.05).There was no significant difference between these two groups in the timing of cough. Vital signs were stable in both groups and no difference was shown in discomforts.CONCLUSION Cisatracurium besilate pretreatment can effectively reduce the incidence and severity of FIC.
Keywords�� fentanyl,   cough,   cistracurium besilate,   pretreatment     
�ո�����: 2013-08-10;
��������:�㽭ʡҽѧ���ٴ������ʽ���Ŀ(2011ZYC-A88)
���߼��: :���һ�, ��, ˶ʿ, ����ҽʦ �о�����:�ٴ�������Σ�ز�ҽѧ Tel:13625751526
���ñ���:   
���һ�, ���主, ����ƽ�� .Ԥע����˳������臨Է�̫���շ����Ե�Ӱ��[J]  �й�ҩѧ��־, 2014,V49(6): 509-511
CHEN Zhong-Hua, ZHOU Qi-Fu, CHEN Nian-Ping etc .Effects of Intravenous Cisatracurium Besilate Pretreatment on Fentanyl-induced Cough[J]  Chinese Pharmaceutical Journal, 2014,V49(6): 509-511
��
[1] TANG Q, QIAN Y, ZHANG Q, et al. Effects of different priming doses of propofol on fentanyl-induced cough during anesthesia induction:A preliminary randomized controlled study. Ups J Med Sci, 2010, 115(2):121-124.[2] ELCOCK D H. Fentanyl-induced cough. Anesthesia, 2010, 65(5):536-537.[3] LIN C S, SUN W Z, CHAN W H, et al. Intravenous lidocaine and ephedrine, but not propofol, suppress fentanyl-induced cough. Can J Anesth, 2004, 51(7):654-659.[4] LIN J A, CHEN F C, LEE M S, et al. Intravenous dexamethasone pretreatment reduceds fentanyl-induced cough.J Formos Med Assoc, 2007, 106(8):649-655.[5] HUNG K C. Incidence of fentanyl-induced cough and injection speed.Acta Anaesthesiol Scand, 2009, 53(9):1227.[6] HAN J I, LEE H, KIM C H, et al. The frequency of fentanyl-induced cough in children and its effects on tracheal intubation. Clin Anesth, 2010, 22(1):3-6.[7] HOMG H C, WONG C S, HSIAO K N, et al. Pre-medication with intravenoue clon-idine suppresses fentanyl-induced cough. Acta Anaesthesiol Scand, 2007, 51(7):862-865.[8] HUNG K C, CHEN C W, LIN V C H, et al. The effect of preemptive minimal dose fentanyl and coughing. Anaesthesia, 2010, 65(1):4-7.[9] LIDA K, HANDA M, FUKUDA, et al. Incidence and onset time of fentanyl-indu-ced cough depends on the dose of IV fentanyl. Masui, 2009, 58(8):962-965. FOLDES F F. Rapid tracheal intubation with nondepolarizing neuromuscular blocking drugs:The priming principle(Letter). Br J Anasesth, 1984, 56(6):663. KOPMAN A F, KHAN N A, NEUMAN G G. Precurarization and priming: A theoretical analysis of safety and timing. Anesth Analg, 2001, 93(5):1253-1256.
[1] ��������������Ф��Ө��������.��������Ⱥ�Ż�֧�������������̫��ѪҩŨ��Ԥ��ģ��[J]. �й�ҩѧ��־, 2013,48(16): 1394-1399
[2] ��������١��֥����־��.�����Ӹ������̫��������ʹ�������ٴ��۲�[J]. �й�ҩѧ��־, 2013,48(14): 1213-1214
[3] ���� ���� ������ ������.Һ��ɫ���������÷��ⶨ��������������Ѫ�������̫���Ũ��[J]. �й�ҩѧ��־, 2012,47(2): 146-148
[4] ������ ���� ��ΰ ������ ���� �����.����þ�����࿨��Թ��IJ�����ȫ���յ��ڼ�ѪҺ����ѧ��Ӱ��[J]. �й�ҩѧ��־, 2011,46(7): 557-558
[5] ���� �Զ��� ��ȫ�� ������ ������ ������ Ԭ����.MDR1�����̬�ԶԸ��ƻ��߷�̫�ᾲ����ʹҩЧѧ��Ӱ��[J]. �й�ҩѧ��־, 2010,45(5): 379-380
[6] �·�Ӣ;����÷;��ǿ;�ݺ���.��ЧҺ��ɫ�׷��ⶨ����֭���������̫��Ũ��[J]. �й�ҩѧ��־, 2009,44(13): 1022-1024
[7] ʩݼ;������;�ⳬ;��һ;��������.��̫��˫�㻺����Ĥ�����Ƽ���������[J]. �й�ҩѧ��־, 2005,39(16): 1234-1237
[8] ʩݼ;������;�ⳬ;��һ;��������.��̫�ᾭ��ǻ�Ĥ���յ��о�[J]. �й�ҩѧ��־, 2005,39(13): 996-998
[9] �Ը߷�;���˰�;��Ⱥ��;�첨;��ΰ��;����.HPLC-UV�ⶨ��Ѫ�����̫��Ũ��[J]. �й�ҩѧ��־, 2005,39(10): 783-785
[10] ������;����;��С��.�������Ӷ�ɫ�׷��ⶨ��Ѫ���з�̫��Ũ��[J]. �й�ҩѧ��־, 1998,33(05): 301-303
Copyright 2010 by �й�ҩѧ��־