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�й�ҩѧ��־ 2012, Vol. 47 Issue (23) :1956-1960    DOI:
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GUO Yin-yin1��2 �� HU Yong-fang1�� ZHANG Hong-yan2�� ZHAO Hui2

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ժҪ Ŀ�� �������Ʊ��������˾���Ⱦҩ�����Ч�ԺͰ�ȫ�ԡ����� ���������PUBMED��1995��2011����Cochrane�ٴ��������ݿ⣨2011���7�ڣ����й��ڿ�ȫ�����ݿ⣨CNKI����1979��2011����ά�����ݿ⣨VIP����1989��2011�����������ݿ⣬�ռ��������Ʊ��������˾��������������������顢ǰհ�Ի�ع��Զ����о����������ų���׼ɸѡ���顢�����о���������ȡ��Ч���ݣ�������RevMan5.0 �������Meta��������� ������8ƪ�������������ף�����544�������а�������/���̹��5�Meta���������ʾ����������/���̹�鱫�������˾���������������������������ҩ��[OR=1.69��95%CI (1.03��2.75)��P=0.04]�������������Ե�������ҩ��[OR=0.51��95%CI(0.29��0.89)��P=0.02]���������ٴ�֢״�����ʡ�ϸ������ʡ�����ʧ�����Լ������¼������ʣ�����������ͳ��ѧ���壨P>0.05����ͷ����ͪ/���̹���о�1������ص��о�4�������ʾ����ҩ��ϸ������ʡ������ʺͲ����¼�������������ҩ����������Բ��죨P>0.05�������������黼�ߵ����������Ը�����������ҩ����[OR=1.76��95%CI(1.09��2.86)��P=0.02]������ ��������/���̹���Ʊ��������˾����¸�Ⱦ�Լ���Ч���������������飬��ȫ�ԽϺá�
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Abstract�� OBJECTIVE To assess the efficacy and safety of different therapeutic regimens for Acinetobacter baumannii infection. METHODS PUBMED (1995 to 2011)��Cochrane Central Register of Controlled Trails (Issue 7��2011)��CNKI (1979 to 2011)��and VIP (1989 to 2011) were searched for randomized controlled trial�� quasi- randomized controlled trial�� prospective and retrospective cohort study. A meta-analysis was performed with Cochrane Collaboration’s RevMan 5.0 software. RESULTS Eight literatures involving 544 patients with Acinetobacter baumannii infection were identified. Five studies used ampicillin/sulbactam. The analysis showed that there was statistically significant difference in the success rate between ampicillin/sulbactam and other drugs with OR of 1.69 and 95% CI of 1.03 to 2.75 and in mortality with OR of 0.51 and 95% CI of 0.29 to 0.89. As for improvement�� bacteriologic success�� treatment failure and adverse events�� there was no statistically significant difference. There was one study involving cefoperazone/sulbactam and four studies on colistin. As far as bacteriologic success�� clinical success and adverse events were concerned�� there was no statistically significant difference. However�� patients receiving colistin treatment had higher mortality with OR of 1.76 and 95% CI of 1.09 to 2.86. CONCLUSION Ampicillin/sulbactam has better effect against Acinetobacter baumannii. It can improve the symptoms and clinical signs and dose not have significant adverse effect.
Keywords�� Acinetobacter baumannii,   Meta-analysis,   ampicillin/subactam,   cefoperazone/subactam,   improvement,   colistin     
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GUO Yin-Yin, HU Yong-Fang, ZHANG Hong-Yan etc .Therapy of Acinetobacter baumannii�� A Systematic Review[J]  Chinese Pharmaceutical Journal, 2012,V47(23): 1956-1960
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[5] BETROSIAN A P�� FRANTZESKAKI F�� XANTHAKI A�� et al. High-dose ampicillin-sulbactam as an alternative treatment of late-onset VAP from multidrug-resistant Acinetobacter baumannii[J]. Scand J Infect Dis�� 2007�� 39(1)�� 38-43.
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