中国药学杂志
    
           首页  |  期刊介绍  |  编 委 会  |  投稿指南  |  期刊订阅  |  广告服务  |  会议信息  |  联系我们  | 
�й�ҩѧ��־ 2011, Vol. 46 Issue (2) :128-133    DOI:
���� ����Ŀ¼ | ����Ŀ¼ | ������� | �߼����� << | >>
��������-���Բ�״��������������-�������ת��ģ���������������ڷֲ��ĴŰ�����
�����1��������1*�����羲2����־��1������1����Ԭ��1���Գо�1���ڳ���1
1.����ҽ�ƴ�ѧ����ҽѧԺ������ 750004�� 2.����ҽ�ƴ�ѧҽѧ��ѧ�����о����ģ����� 750004
BAO Feng-juan1�� GOU Guo-jing1*�� WANG Shu-jing2�� WANG Zhi-Yu1�� WANG Rui1�� JIANG Yuan-xu1�� ZHAO Cheng-jun1��HEI Chang-chun1
1.Ningxia Medical University�� Yinchuan 750004��China��2. Research Center of Medical Science and Technology�� Ningxia Medical University�� Yinchuan 750004�� China

Download: PDF (1299KB)   HTML (0KB)   Export: BibTeX or EndNote (RIS)      Supporting Info
ժҪ Ŀ�� �о���������-���Բ�״��������������-�������ת��ģ���ڴ�������ҩ��ֲ��ĴŰ����ԡ����� ������ЧҺ��ɫ���ڱ귨���ⶨ��ҩ��������ڸ���֯�ķ�����षֲ�Ũ�ȣ�������ֹ��ȷ���ԭ�����շ����������巢����׷��ⶨ��ҩ��Ԥ��������֯���ķֲ�Ũ�ȣ�ͨ����³ʿ����Ⱦɫֱ������������֯�ֲ����졣��� ��ЧҺ��ɫ���ڱ귨�����ʸߡ����ܶȺã�����ǻע���ҩ�󣬱��Ҳ༰ͷ�������ų���λ��ҩ��Ũ�����Ը�������Զ��ų�����֯��λ����ֵ�ֲ���ͳ��ѧ���壬֤����������ģ�;�������ĴŰ�����תЧ�������� ����Ӵų��������£���������-���Բ�״��������������-�������ת��ģ�����ڰ���λ���Ը������������õĴŰ����ԡ�
Service
�ѱ����Ƽ�������
�����ҵ����
�������ù�����
Email Alert
RSS
�����������
�ؼ����� �������   �Ű���ת��ģ��   ��ЧҺ��ɫ���ڱ귨   ��³ʿ����Ⱦɫ     
Abstract�� OBJECTIVE To observe the magnetic targeting drug bio-distribution of the transshipment model with a form of Dextran -Magnetic LDH- Fluorouracil in rats. METHODS A HPLC method was established to determine the concentration of 5-Fu in tissues. The ultraviolet spectro-photometry�� flame atomic absorption spectrometer and the inductively coupled plasma were used to detect the iron concentration in mouse tissues�� and Prussian blue iron stain was employed for observing the different of iron bio-distribution in tissues. RESULTS The established HPLC method had high recovery and a good precision. After administration via peritoneal injection��the magnetic field had been set up in right of the back and the head�� and the drug concentration were significant higher than other parts which were far away from the magnetic field. Drug concentration distribution showed statistical significance. This ternary composite model had an ideal magnetic targeting transfer effect. CONCLUSION Under the influence of an external magnetic field�� the Dextran -Magnetic LDH- Fluorouracil transshipment model could be significantly enriched in the target area to show a good magnetic targeting.
Keywords�� 5-fluorouracil,   magnetic targeted transshipment model,   HPLC internal rat method,   prussian blue iron stain     
�ո�����: 2011-11-11;
���ñ���:   
.��������-���Բ�״��������������-�������ת��ģ���������������ڷֲ��ĴŰ�����[J]  �й�ҩѧ��־, 2011,V46(2): 128-133
.Magnetic Targeted Bio-distribution of Dextran-Magnetic LDH-Fluorouracil Transfer Model in Natural Rats[J]  Chinese Pharmaceutical Journal, 2011,V46(2): 128-133
��
[1] LUBBE A S�� ALEXION C�� BERGEMANN C. Clinical application of magnetic drug targeting[J]. J Surg Res��2001��95(2��200-206. [2] GUO Y H, YAN W H, GUI L, et al. Targeted biodistribution of carboplatin-Fe@C nanocage-loaded chitosan nanoparticles in rats[J]. Chin Pharm J (�й�ҩѧ��־��2009,44 (21 : 1648-1652.[3] TORCHILIN V P. Drug targeting[J]. Eur J Pharm Sci��2000��11��81-91. [4] GOU G J, BAO F J, YANG J H. Preparation of magnetic LDH with a nitrogen-hydrogen preserve coprecipitation method : China, 101607088A[P].2009-12-23.[5] GOU G J, BAO F J, JIANG Y X. Preparation of the magnetic targeted and extended release tripolymer with a packed structure of "dextran-magnetic LDH-fluorouracil" : China, 101607088A[P]. 2009-12-23.[6] GOU G J, BAO F J, ZHENG Z X, et al. Structure and property characterization of Mg Al type layered double hydroxides intercalated with antineoplastic drug fluorouracil [J]. Chem Res Appl (��ѧ�о���Ӧ��, 2008��20(9:1158-1162.[7] ZHI P X�� QING H Z��GAO Q L�� et al. Inorganic nanoparticles as carriers for efficient cellular delivery[J]. Chem Eng Sci�� 2006��61��3��1027-1040. [8] KWAK S Y�� KRIVEN W M�� CHOY J H�� et al. Inorganic delivery vector for intravenous injection[J]. Biomaterials�� 2004�� 25��28�� 5995-6001. [9] AZZAM T�� DOMB A J. Current development in gene transfection agents[J]. Curr Drug Deliv�� 2004�� 1��1�� 165-193. [10] CHRISTOPH A�� WOLFGANG A�� PETER H�� et al. Magnetic mitoxantrone nanoparticle detection by histology��X-ray and MRI after magnetic tumor targeting[J]. J Magn Magn Mater��2001��225��1-2�� 187-193. [11] GOU G J�� LIU J P�� XU H P�� et al. Loading and in vitro release of acetylsalicylic acid via layered double hydroxides[J]. Acta Chem Sin(��ѧѧ��. 2009��67(1�� 65-82. [12] DI PAOLO A�� DANESI R�� FALCONE A�� et al. Relationship between 5-fluorouracil disposition�� to xicity and dihydropyrimidine dehydrogenase activity in cancer patients[J]. Ann Oncol�� 2001�� 12(9�� 1301-1306. [13] FAROKHZAD O C�� KHADEMHOSSEINI A. Nanoparticle-aptamer bioconjugates�� a new approach for targeting prostate cancer cells[J]. Cancer Res�� 2004�� 64(21��27668-27672. [14] SOMA C E�� DUBERNET C�� BENTOLILA D�� et al. Reversion of multidrug resistance by co-encapsulation of doxorubicin and cyclosporin A in polyalkylcyanoacrylate nanoparticles[J]. Biomaterials��2000��21(1��127. [15] ZHENG J W, XU R, TANG T, et al. Targeting Distribution of 5-Fu Magnetic Nanoparticles in Nude Mice Bearing Hepatoma [J]. Acta Med Univ Sci Technol Huazhong (���пƼ���ѧѧ�� ҽѧ��, 2007, 36(2:202-205.
[1] �ͺ��� �Ⱥ�ΰ �ƾ��� ����÷ ������ ���ջ� .������ा۱������ҽ���-���Ҷ������׻������������Ʊ��������ͷŵ��о�[J]. �й�ҩѧ��־, 2011,46(23): 1814-1817
[2] ������ ���� ����Ԫ �����٩~.�����ǻ��Ǿ���-�������ż����ĺϳ������[J]. �й�ҩѧ��־, 2011,46(21): 1677-1680
[3] ���� ³���� л���� ��Сΰ ³��.��������п�΢���Ʊ����պ���ҩ��Ϊ���о�[J]. �й�ҩѧ��־, 2011,46(10): 761-765
[4] ������ ����.ǰҩҶ��-ţѪ��׵���-�������ż�������������ڷֲ���ҩЧѧ�о�[J]. �й�ҩѧ��־, 2010,45(2): 107-110
[5] Ф���� �ι��� �ι��� ������ �ijɲ� ������.��������¶�����ԭλ�������Ʊ������ܱ���[J]. �й�ҩѧ��־, 2010,45(11): 838-843
[6] �;����;��ʥ��.5-������ाۼ�������״ֲ������о�[J]. �й�ҩѧ��־, 2009,44(08): 602-606
[7] ������;������;��ʥ��.S/O/W���Ʊ�������ऻ���΢����������ҩ��Ϊ����[J]. �й�ҩѧ��־, 2009,44(03): 205-208
[8] ����;�Զ�;����;��־��.�������-���������ؽ������LoVoϸ���Ľ�������о�[J]. �й�ҩѧ��־, 2008,43(15): 1153-1156
[9] ������;������;���׷�;��һ.������िɽ���΢��-������ҩϵͳ�Ĺ���[J]. �й�ҩѧ��־, 2008,43(11): 844-847
[10] ������ ;��Ԫ־;����;����ʤ;�δ���;������;�⾲;��÷.�������ֲ����ڵ��ױ��Լ���������Ϊ�о�[J]. �й�ҩѧ��־, 2008,43(05): 360-364
[11] ����;����.�����������ø������5-���������Ч�Ͷ��ԵĹ�ϵ[J]. �й�ҩѧ��־, 2007,42(19): 1441-1445
[12] ������;���;�׵���;�ܷ�;�����;�ƽ���;˹½��.������र׵��״�����΢�������о�[J]. �й�ҩѧ��־, 2007,42(08): 598-600
[13] ���־�;�ƹ�;ϯ����;���Ķ�;�˼ͷ�.�������pH����-ʱ���ͽ᳦��λ΢����Ʊ�����ҩ�����о�[J]. �й�ҩѧ��־, 2007,42(05): 357-361
[14] Ҷ��;����;��ǿ;��ǿ;é��.��ӷ�������֯��͸����������ת����ҩ��ѧ�о�[J]. �й�ҩѧ��־, 2007,42(01): 48-52
[15] �̴�;����;�;����;����.�ΰ���ǰҩ�����ǻ���Ѫ��׵��׷������ż����ĺϳɼ���������[J]. �й�ҩѧ��־, 2006,41(10): 786-789
Copyright 2010 by �й�ҩѧ��־