Abstract��
OBJECTIVE To investigate the influence of semi-synthetic high fat diet and synthetic high fat diet on glucose and lipid metabolism in Wistar rats. METHODS Male Wistar rats were randomly divided into 3 groups�� control group (Con�� n=7 fed with standard chow diet�� high fat group 1 (HF1�� n=7 fed with synthetic high fat diet�� and high fat group 2 (HF2�� n=7 fed with semi-synthetic high fat diet. Body weight�� energy intake�� and fasted serum lipid level (total triglyceride�� TG and total cholesterol�� TC of the rats were monitored. Oral glucose tolerance test (OGTT and insulin tolerance test (ITT were performed. RESULTS Weight gain in the first week�� hyperlipidemia in the second week�� and impaired glucose tolerance and insulin resistance in the fourth week were observed in the rats fed with semi-synthetic high fat diet or synthetic high fat diet compared with control group. CONCLUSION The rats fed with semi-synthetic high fat diet or synthetic high fat diet have the characteristics of abnormal glucose and lipid metabolism�� such as obesity�� impaired glucose tolerance�� insulin resistance and hyperlipidemia. Semi-synthetic high fat diet is superior in inducing abnormal glucose and lipid metabolism.
.Influence of Semi-Synthetic High Fat Diet and Synthetic High Fat Diet on Glucose and Lipid Metabolism in Rats[J] Chinese Pharmaceutical Journal, 2011,V46(10): 753-756
2011, Vol. 46 
