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�й�ҩѧ��־ 2011, Vol. 46 Issue (10) :753-756    DOI:
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�й�ҽѧ��ѧԺ-����Э��ҽѧԺҩ���о��������� 100050
LIU Jun-yang�� HE Yi-bo�� YE Fei*
Institute of Materia Medica�� Chinese Academy of Medical Sciences & Peking Union Medical College�� Beijing 100050�� China

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Abstract�� OBJECTIVE To investigate the influence of semi-synthetic high fat diet and synthetic high fat diet on glucose and lipid metabolism in Wistar rats. METHODS Male Wistar rats were randomly divided into 3 groups�� control group (Con�� n=7 fed with standard chow diet�� high fat group 1 (HF1�� n=7 fed with synthetic high fat diet�� and high fat group 2 (HF2�� n=7 fed with semi-synthetic high fat diet. Body weight�� energy intake�� and fasted serum lipid level (total triglyceride�� TG and total cholesterol�� TC of the rats were monitored. Oral glucose tolerance test (OGTT and insulin tolerance test (ITT were performed. RESULTS Weight gain in the first week�� hyperlipidemia in the second week�� and impaired glucose tolerance and insulin resistance in the fourth week were observed in the rats fed with semi-synthetic high fat diet or synthetic high fat diet compared with control group. CONCLUSION The rats fed with semi-synthetic high fat diet or synthetic high fat diet have the characteristics of abnormal glucose and lipid metabolism�� such as obesity�� impaired glucose tolerance�� insulin resistance and hyperlipidemia. Semi-synthetic high fat diet is superior in inducing abnormal glucose and lipid metabolism.
Keywords�� semi-synthetic high fat diet,   synthetic high fat diet,   abnormal glucose and lipid metabolism     
�ո�����: 2011-11-11;
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.��ϳɸ�֬���Ϻͺϳɸ�֬���϶Դ�����֬��л��Ӱ��[J]  �й�ҩѧ��־, 2011,V46(10): 753-756
.Influence of Semi-Synthetic High Fat Diet and Synthetic High Fat Diet on Glucose and Lipid Metabolism in Rats[J]  Chinese Pharmaceutical Journal, 2011,V46(10): 753-756
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