Abstract��
OBJECTIVE To study a new preparation process of 5-fluorouracil hollow microcapsules�� and to investigate the influence of porogen on the release behavior of microcapsules. METHODS PEG was added to PVA�� the capsule wall material�� as porogen. Suspension interfacial cross-linking method was adopted to prepare 5-flurouracil hollow microcapsules. To optimize the preparation process of PVA microcapsules�� the particle size�� drug-loading rate�� and encapsulation efficiency were examined. In order to study the effect of porogen�� the total amount of in vitro drug release was examined. RESULTS Microcapsules prepared by this process have completely hollow structure. The average diameter of the microcapsules was 22 ��m. The drug- loading rate and encapsulation efficiency were 15.6% and 84.8%�� respectively. For the porogen added microcapsules�� the 24 h in vitro drug release rate was 93.2%. CONCLUSION The suspension cross-linking method can be used to prepare hollow microcapsules. The hollow structure of microcapsules may increase drug-loading rate. When porogen is added in the wall material�� incomplete drug release are overcame. The microcapsules has sustained release in vitro.
2011, Vol. 46 
