中国药学杂志
    
           首页  |  期刊介绍  |  编 委 会  |  投稿指南  |  期刊订阅  |  广告服务  |  会议信息  |  联系我们  | 
�й�ҩѧ��־ 2011, Vol. 46 Issue (20) :1574-1576    DOI:
���� ����Ŀ¼ | ����Ŀ¼ | ������� | �߼����� << | >>
���������ڸ����е�Ӧ�ü������������˼�����Ե��о�
����ԣ���ƽ*����ӥ�壬�׻�������ǣ�����������ˬ
�й���ҽ��ѧԺ����ҽԺ������ 100102
LI Guo-hui�� ZHANG Ping*�� JIA Ying-jue��KONG Huan-yu�� LIN Nan-xing�� ZHANG Rui-li�� SU Shuang
Wangjing Hospital of China Academy of Chinese Medicine Sciences�� Beijing 100102�� China

Download: PDF (1081KB)   HTML (0KB)   Export: BibTeX or EndNote (RIS)      Supporting Info
ժҪ Ŀ�� ͨ���۲���ױ��¶�����ģ��С��Ĵ���Ƥ��ͺ������IJ���ı䣬̽�ֲ�ͬ����������ζҩ�����ڻ����ⶾ���е����񾭶��ԣ�Ϊ�ٴ�����ʹ�û����ṩ������ʵ�����ݡ����� ����������1��5�鼰�����ⶾ��������1��5��ֱ���躬������ҩ3.0��2.25��1.5��0.75��0.3 g��kg-1ˮ��ҩҺ������ҩ����谢˾ƥ��0.2 g��kg-1���������ģ���������������ˮ������θ��ҩ������5 d��ÿ��1�Ρ���ĩ�θ�ҩ��30 min�ö��ױ�ͿĨС�������ģ���Ѿʴ�����ȡ����֯�����Թ̶�Һ�У���Ƭ��HE��Ⱦɫ������΢���¹۲������Ƥ�㼰������������������ �հ��顢ģ���顢����ҩ��С�����Ƥ��ͺ������������1��4���У�����С�����Ƥ��ͺ�����֯���в�ͬ�̶ȵı��ԣ�����������Ӷ���ǿ��������ҩ���н�1�飨3.0 g��kg-1����2�飨2.25 g��kg-1��С�����Ƥ��ͺ�����֯��С������΢���ԣ����������������������� ������0.75 g��kg-1��ҩ5 d�������С���������ˣ������������˼��أ����ڻ����ⶾ����Ӧ�����Ϊ��ȫ��
Service
�ѱ����Ƽ�������
�����ҵ����
�������ù�����
Email Alert
RSS
�����������
�����
��ƽ*
��ӥ��
�׻���
������
������
�����
��ƽ*
��ӥ��
�׻���
������
������
�ؼ����� ����   �����ⶾ��   ����Ƥ��   ������   �񾭶���     
Abstract�� OBJECTIVE To explore the cranial nerve toxicity of different doses of Rhizoma Coptis and Huanglian Jiedu decoction (HJD) by observing pathological changes of the cerebral cortex and hippocampus in mice with xylene-induced ear swelling. METHODS Mice in the treatment groups were orally administered different doses of Rhizoma Coptis and HJD�� while those in the positive control group were given aspirin as a standard drug. Mice in the normal group and the control group were given equal volume of water. Each group was given medicine for 5 d. Xylene-induced ear swelling model in mice was induced after the 5th day medication. Then the mice were sacrificed�� and their brains were taken out for paraffin processing. The pathological changes of the cerebral cortex and hippocampus were observed under microscope. RESULTS The cerebral cortex and the hippocampus of the mice in the normal group and the control group were all normal�� The cerebral cortex and hippocampus of the mice in Rhizoma Coptis group 1-4 were damaged in varying degrees�� and the damages were dose-dependent. HJD group 1-2 had a slight damage�� the rest 3 groups were normal. CONCLUSION Rhizoma Coptis can result incranial nerve damage in mice when given at 0.75 g��kg-1 for 5 d�� and the damage is dose-dependent. But when Rhizoma Coptis is applied as Huanglian Jiedu Decoction�� it is safer.
Keywords�� Rhizoma Coptis,   Huanglian Jiedu decoction (HJD),   cerebral cortex,   hippocampus,   cranial nerve toxicity     
�ո�����: 2011-11-11;
���ñ���:   
�����, ��ƽ*, ��ӥ��� .���������ڸ����е�Ӧ�ü������������˼�����Ե��о�[J]  �й�ҩѧ��־, 2011,V46(20): 1574-1576
LI Guo-hui, ZHANG Ping, JIA Ying-jue etc .Correlation Study between Cranial Nerve Toxicity and Doses of Rhizoma Coptis and Huanglian Jiedu Decoction[J]  Chinese Pharmaceutical Journal, 2011,V46(20): 1574-1576
��
[1] DAI G Y�� PAN X O�� LUO H X. Advances in pharmacological studies of Coptis [J]. Chin Pharm(�й�ҩ��)��2004��15(11)��694-696. [2] TAN Z H�� TANG D X�� LI H Y. Study on interactions among drugs in Xiexin decoction[J]. Chin J Exp Tradit Med Form(�й�ʵ�鷽��ѧ��־)�� 2010��16(4)��99-102. [3] QIU S H�� TANG H B�� LI F Y�� et al. Experimental study of the acute toxicity on conunon-used bitter and cold medicines[J]. Cent South Pharm(����ҩѧ)�� 2004��2(1)��37-38. [4] JIA Y J�� LI G H�� ZHANG P. Research on acute toxicity of Rhizoma Coptidis and Huanglian Jiedu Decoction[J]. Chin Pharm J���й�ҩѧ��־����2011��46��18����492-497.[5] LI G H�� JIA Y J��KONG H Y��et al. Dose-effect relationship of Rizoma Coptidis and Huanglian Jiedu Decoction[J]. Chin Pharm J���й�ҩѧ��־���� 2010�� 45(13)��987-990. [6] CHEN Q. Pharmacology Experimental Methodology(ҩ��ʵ�鷽��ѧ) [M]. Beijing�� People��s Medical Publishing House��1993��112�� 356.[7] HE X S�� ZHOU N N�� DAI R�� et al. Experimental study of anti-inflammatory�� antibacterial and choleretic effect of Jinxiong Yanbike capsules [J]. Chin J Tradit Med Sci Technol (�й���ҽҩ�Ƽ�)��2004��11(2)��86-87. [8] LI J R��GAO X S��LIU D. Study on interactions to acute toxicity and the berberine content influence[J]. Chin Med Inf Tradit Chin Med(�й���ҽҩ��Ϣ��־)�� 1999��6(10)��32-33.
[1] ��ӥ�� ����� ��ƽ.�����������ⶾ����С��ļ��Զ���ʵ���о�[J]. �й�ҩѧ��־, 2011,46(18): 1399-1404
[2] ʷ���� ������ ������ ������ ������ л���� �ž�.�����ɽ�ҩ�ԶԹ�����������������θ�ſպ�Ѫ��θ���ص�Ӱ��[J]. �й�ҩѧ��־, 2011,46(13): 988-992
[3] ����� ��ӥ�� �׻��� ���ع� ���� ������ ����ΰ �ź��� ��־��.��ζ���������ڸ����е���Ч��ϵʵ���о�[J]. �й�ҩѧ��־, 2010,45(13): 987-990
[4] ���� ���ᄃ ������ . ���������նԸ�������ϵĤϸ���ڷ�ø�ǻ���������Ӧ����Ӱ��[J]. �й�ҩѧ��־, 2009,44(22): 1695-1698
[5] �ű����������棬�½��� . �����ⶾ��ҩЧѧ�о��ſ�[J]. �й�ҩѧ��־, 2009,44(16): 1204-1207
[6] ���޻� ;�쾧��;������;����ΰ.һ��������ⶨ������С�޼����͡���������С�޼ҩ�����[J]. �й�ҩѧ��־, 2009,44(05): 390-394
[7] ���� ;������ ;�����;������;�޹���.�һ����������΢����Ʊ�����������[J]. �й�ҩѧ��־, 2008,43(21): 1633-1637
[8] �ƿ���;����;�����;�߻���;������;������.���غ������Ļ�ѧ�ɷ�[J]. �й�ҩѧ��־, 2008,43(18): 1382-1385
[9] ���޻� ;�쾧��;������;���¾�.������ҩ��ֲ�ﻯѧ�ɷֺ��������Ƶ��о���չ[J]. �й�ҩѧ��־, 2008,43(15): 1121-1125
[10] �¹�;½����;����;������;����;������;л��;����.��������������ЧӦ�ɷ�������������öȵ��о�[J]. �й�ҩѧ��־, 2008,43(09): 696-698
[11] ���;�����;�。;���Ľ�;������.�����ⶾ����MPP+�յ���PC12ϸ�����˵ı�������[J]. �й�ҩѧ��־, 2008,43(05): 344-348
[12] ʯ��;��Խ��;����;Ҷ����;������.�����ͻ�ͪ��ɷ���к�������������еĺ����о�[J]. �й�ҩѧ��־, 2007,42(23): 1770-1773
[13] ����;������;����;������.˫�����������ͷ�������������ڼ�������ҩ��ѧ�໥Ӱ��[J]. �й�ҩѧ��־, 2006,41(18): 1411-1413
[14] �ᄚ�� ;����÷;������;������.���������������յ��о�[J]. �й�ҩѧ��־, 2005,39(15): 1133-1134
[15] ����ʤ;����÷;������;��ƽ��.�����������Ƿּ������ʱ��Ҫ��ֺ����仯�����о�[J]. �й�ҩѧ��־, 2005,39(04): 258-260
Copyright 2010 by �й�ҩѧ��־