SUI Da-yuana��YU Xiao-fenga��QU Shao-chuna��XU Hua-lia��WANG Shaob
a.Department of Pharmacology��School of Pharmacy ��b.Department of Physiology�� School of Basic Medical Sciences�� Jilin University��Changchun 130021�� China
Abstract��
OBJECTIVE To study the effects of Panax quinquefolium 20s-protopanaxdiolsaponins (PQDS)extracted from leaves of Panax quinquefolium on experimental ventricular remodeling in rats. METHODS The ventricular remodeling model was induced by myocardial infarction for 4 weeks in rats with left anterior descending coronary occulusion. After 4 weeks of treatment with PQDS, hemodynamic changes, biochemical analysis and morphological parameters were determined in ventricular remodeling rats with myocardial infarction. RESULTS After being treated by PQDS (in a dosage of 25��100 mg��kg-1 ip for 4 weeks),the maximum left ventricular pressure rising and dropping rates (��dp/dtmax)and their left ventricular systolic pressure corrected values(��dp/dtmax/LVSP)were increased significantly. The left ventricular end diastolic pressure (LVEDP), the left ventricular volume(LVV), the left ventricular long and short axis(LVLA and LVSA) , the left ventricular absolute and relative weight (LVAW and LVRW) were reduced significantly, but there were no significant influences on the right ventricular absolute and relative weight (RVAW and RVRW) , the heart rate (HR), the left ventricular systolic pressure(LVSP), mean artery pressure (MAP) and body weight (BW). In addition, the serum lipid peroxidation (LPO) content, myocardial angiotensin ��(Ang��) and epinephrine (E) contents were declined, and the serum superoxide dismutase(SOD), catalase(CAT) and glutathione peroxidase (GSH-Px) activities were increased markedly.CONCLUSION PQDS can efficiently prevent and treat ventricular remodeling in rats with myocardial infarction, which may be related to the inhibition of promoting growth action of Ang�� and CA,and the elimination of the free radicals in rats with ventricular remodeling induced by myocardial infarction.
.Effects of Panax quinquefolium 20s-protopanaxdiol Saponins on Experimental Ventricular Remodeling in Rats [J] Chinese Pharmaceutical Journal, 2007,V42(02): 108-112
2007, Vol. 42 
