Abstract��
OBJECTIVE To study pharmacokinetic interaction of Shuanghuanglian powder for injection and cefazolin in rabbit.METHODS 15 rabbits were divided into three groups randomly.Serum samples were collected at different time after intravenously single dose of Shuanghuanglian,cefazolin or their mixture.The data obtained were fitted with Practical Pharmacokinetic Program-Version 97(3P97).RESULTS The mean serum concentrations of baicalin after iv Shuanghuanglian or mixed drugs in rabbits were fitted to a two-compartment model with a weight of 1/C2.The main pharmacokinetic(PK) parameters of baicalin in two groups were as follows,respectively:t1/2�� 6.66 and 6.68 min,t1/2�� 118.77 and 48.23 min,Vc 0.086 6 and 0.108 2 L��kg-1,AUC0-t 8.98 and 7.36 kg��min��L-1,AUC0-�� 9.20 and 7.47(kg��min��L-1),MRT0-t 14.19 and 13.75 min,MRT0-��) 17.91 and 15.94 min,CLs 0.007 9 and 0.010 4 L��min-1��kg-1.The mean serum concentrations of cefazolin after iv cefazolin or mixed drugs in rabbits were fitted to a two-compartment model with a weight of 1/C2.The main PK parameters of cefazolin in two groups were as follows,respectively: t1/2�� 11.68 and 14.36 min,t1/2�� 46.85 and 55.59 min,Vc 0.166 9 and 0.143 9 L��kg-1,AUC0-t36.20 and 56.49 kg��min��L-1,AUC0-�� 36.51 and 57.33 kg��min��L-1,MRT0-t) 40.28 and 48.07 min,MRT0-�� 42.55 and 51.72 min,CLs 0.005 7 and 0.003 6 L��min-1��kg-1.CONCLUSION There are no significant differences for PK parameters of the baicalin except increasing of Vc after iv mixed drugs.While the PK parameters of cefazolin change largely after iv mixed drugs.The serum concentration,AUC and MRT0-t increase and CL(s) decreases.
FANG Yan,
CHEN Li-ming,
DAI Min etc
.Pharmacokinetic Interaction of Shuanghuanglian Powder for Injection and Cefazolin in Rabbit [J] Chinese Pharmaceutical Journal, 2006,V41(18): 1411-1413
2006, Vol. 41 
