Abstract��
OBJECTIVE: To study the neuroprotective effects of berberine (Ber) on cultured central neuronal injuries induced by oxidative stress. METHODS: Cytotoxicities of glutamate (Glu 500mol��L-1,15min),hemoglobin (Hb 100mol��L-1,24h) or "ischemia (6h)/reperfusion(24h)" and protective effects of Ber on cultured rat cortical neurons were observed. RESULTS: Exposure of rat fetus cerebral cells to Glu,Hb or hypoxic/hypoglycemic medium developed a neurotoxicity expressed in the increase of LDH leakage and MDA content and the decrease of GSH content,as well as the development of morphological injury.Ber (1��25mol��L-1) significantly protected neurons against above damages. CONCLUSION: Ber protected cerebral cells from the injuries induced by oxidative stress via increasing the content of GSH and inhibiting lipid peroxidation.
.Protective effects of berberine on cultured central neuronal injuries induced by oxidative stress[J] Chinese Pharmaceutical Journal, 1999,V34(08): 525-529
1999, Vol. 34 
