Abstract��
OBJECTIVE To establish a METHOD for determining the dissolution of low dosage aspirin enteric��coated tablets (LDAET).METHODS The cup method was used to determine the dissolution of LDAET.The uniform design was employed to select the conditions of dissolution determination of LDAET,in which the dissolution volume,the rotational speed,and dissolution time were three main factors in four levels and the differential value of dissolution of Yb-a was the inspecting index.RESULTS The dissolution conditions of LDAET were optimized as the rotational speed 100 r��min-1 and dissolution volume 100 mL.The dissolution of LDAET in six of nine batches was over 70% within 45 minutes and completed within 1 hour,but three in nine batches was only of 8%��50%.CONCLUSION The experiment results showed that the dissolution conditions of LDAET could be defined as the standard.
.Studies on dissolution conditions for low dosage aspirin enteric��coated tablet by uniform design[J] Chinese Pharmaceutical Journal, 2003,V38(03): 198-200
2003, Vol. 38 
