Abstract��
A Bayesian approach was developed to predict the non-steady phenytoin. TheBayesian program was developed from the simplified model of professor Beal. The non-steadyphenytoin concentration was calculated by using the Bayesian combined with the population phar-macokinetic parameters of phenytoin. The relationship between the observed and predicted con-centration reached 96%in 6 patients with one point of concentration. The predicted error was lessthan 10%. The results show that the method can be successfully used in the predictoin of pheny-toin under the complex conditoin of phenytoin administration.
Lu Jianfeng,
Zhou Yonggang,
Yang Youchun etc
.Application of Bayesian feedback method in the prediction of non-steadyphenytoin concentrations[J] Chinese Pharmaceutical Journal, 1995,V30(12): 738-740
1995, Vol. 30 
