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�й�ҩѧ��־ 2009, Vol. 44 Issue (14) :1119-1120    DOI:
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.���ܦ̰�Ƭ�����׿���������׻�����ͪ[J]  �й�ҩѧ��־, 2009,V44(14): 1119-1120
.[J]  Chinese Pharmaceutical Journal, 2009,V44(14): 1119-1120
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[1] FDA Approves Relistor for Opioid-Induced Constipation[EB/OL]. FDA News��April 24��2008[2008-11-15]. Http://www.fda.gov/bbs/ topics/NEWS/2008/NEW01826.html
[2] YUAN C S, FOSS J F. Gastric effects of methylnaltrexone on mu, kappa, and delta opioid agonists induced brainstem unitary responses[J]. Neuropharmacology,1999,38(3): 425-432.
[3] Relistor package insert[EB/OL]. Philadelphia,PA: Wyeth Pharmace uticals, Inc[2008-11-15]. Http://www.rxlist.com/relistor- drug.htm
[4] YUAN C S, FOSS J F, O��CONNOR M, et al. Methylnaltrexone for the reversal of constipation due to chroinc methadone use:A randomised clinical trial[J].JAMA 2000,283(3):367-372.
[5] YUAN C S,FOSS J F, O��CONNOR M, et al. Methylnaltrexone prevents morphine-induced delay in oral-cecal transit time without affecting analgesia:a double-blind randomized placebo-controlled trial[J].Clin Pharmacol Ther, 1996, 59(4):469-475.
[6] MURPHY D B, SUTTON J A, PRESCOTT L F, et al.Opioid-induced delay in gastric emptying: A peripheral mechanism in humans[J]. Anesthesiology, 1997,87(4):765-770.
[7] YUAN C S, WEI G, FOSS J F, et al. Effects of subcutaneous methylnaltrexone on morphine-induced peripherally mediated side effects: A double-blind randomized placebo-controlled trial[J].J Pharmacol Exp Ther, 2002, 300(1): 118-123.
[8] YUAN C S, FOSS J F, OSINSKI J, et al. The safety and efficacy of oral methylnaltrexone in preventing morphine-induced delay in oral-cecal transit time[J]. Clin Pharmacol Ther ,1997, 61(4): 467-475.
[9] KARVER S B, SLATKIN N E, THOMAS J, et al. Methylnaltrexone treatment of opioid-induced constipation in cancer patients[C] J Clin Onco, 2007,25(18)��9081.
[10] THOMAS J, KARVER S B, COONEY G A, et al. Phase III Results From Two Multi-Center Randomized Double-Blind Placebo- Controlled Trials Of Methylnaltrexone For Opioid-Induced Constipation (OIC) In Patients With Advanced Illness (AI)[EB/OL]. American Academy of Pain Management: 23rd Annual Meeting,New Orleans, LA, February 7-10,2007[2008-11-16].http://aapm.confex. Com/aapm/2007am/techprogram/P1981.HTM
[11] THOMAS J, KARVER S B, COONEY G A, et al. Methylnaltrexone for opioid-induced constipation in advanced illness[J]. N Engl J Med 2008; 358(22):2332-2343.
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