1.State Key Laboratory of Natural and Biomimetic Drugs��Peking University��Beijing 100191��China��2.School of Pharmaceutical Science��Peking University��Beijing 100191��China��3.Department of Pharmacy��General Hospital of Shenyang Military Region��Shenyang 110016��China
Abstract��
OBJECTIVE To construct the population pharmacokinetic(PPK) model of tinidazole in five major ethnic populations in China for individualized drug therapy in clinical practice.METHODS The population pharmacokinetic model of tinidazole was developed for 50 healthy subjects from Han,Mongol,Korean,Hui and Uighur nationality,the major 5 nationalities of China after oral administration.The effects of demography and biochemical covariates were investigated by NONMEM.Internal and external validations were conducted for the model.RESULTS A two-compartment model with first-order absorption and elimination process was confirmed as structure model of tinidazole.The population typical values and relative standard errors(RSE) of CL1,CL2,V1,V2 and Ka were 0.807(10.7%)L��h-1,205(9.32%)L��h-1,3.29(17.7%)L,19.0(15.4%)L and 1.51(8.28%) h-1 respectively.The result showed that race and body weight covariates showed significant influence on CL1(P<0.001).Race and gender covariates showed significant influence on V1(P<0.001).Body weight covariate showed significant influence on V2(P<0.001).CONCLUSION The final PPK model of tinidazole in for 5 major Chinese nationalityies was established by NONMEM.The PPK model was steady and reliable.
2009, Vol. 44 
