An Overview of Synthesis and Bioactivities of Derivatives Based on the Structure of Natural Product Piperlongumine
LONG Xue-sha1, WANG Qin1, WANG Cong-yu1, WANG Zhen-chao1,2,3*, OUYANG Gui-ping1,2,3*
1. School of Pharmaceutical Science, Guizhou University, Guiyang 550025, China; 2. Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University,Guiyang 550025, China; 3. Guizhou Engineering Laboratory for Synthetic Drugs, Guiyang 550025, China
Abstract：Piperlongumine is an alkaloid derived from Piper longum L. Through studies on piperlongumine and its derivatives, scientists have found that piperlongumine has a wide range of physiological activities, including anti-inflammatory, neuroprotective, anti-insect, anti-liver fibrosis, anti-vascular calcification, anti-tumor, etc. There are mainly three reaction sites in the structure of piperlongumine. Starting from piperlongumine, this paper elaborates the synthesis of piperlonguine and its derivatives, the biological activities of these compounds, and the mechanism of action according to the clues of different reaction sites. It provides scientific basis for the research and development of new drugs based on piperlongumine.
龙雪莎, 王钦, 汪从雨, 王贞超, 欧阳贵平. 天然荜茇酰胺衍生物合成及生物活性研究进展[J]. 中国药学杂志, 2022, 57(22): 1865-1872.
LONG Xue-sha, WANG Qin, WANG Cong-yu, WANG Zhen-chao, OUYANG Gui-ping. An Overview of Synthesis and Bioactivities of Derivatives Based on the Structure of Natural Product Piperlongumine. Chinese Pharmaceutical Journal, 2022, 57(22): 1865-1872.
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