Regulation of the Pre-metastatic Niches on Lung Cancer Metastasis and Its Clinical Application
ZHANG Ming-yu, LI Chun-yu, LI Guo-hui*
National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Abstract：Lung cancer is one kind of malignant tumors with the highest morbidity and mortality, and lung cancer metastasis is the leading cause of death in patients. Lung cancer metastasis is a complex process. A large number of studies have confirmed that lung tumors can secrete soluble molecules, mobilize and recruit related bone marrow cells or immune cells, regulate the matrix remodeling in distant organs which leads to the formation of pre-metastatic niche, therefore, promote tumor cells metastasis and implantation in distant organs. Detection of key target factor molecules and cellular components involving in pre-metastatic niche is of great clinical significance for diagnosis and prognostic evaluation. This article will summarize the progression of lung cancer metastasis modulated by the pre-metastatic niches and its clinical application status.
张铭予, 李春雨, 李国辉. 转移前微环境调控对肺癌转移的影响及临床应用现状[J]. 中国药学杂志, 2020, 55(11): 871-874.
ZHANG Ming-yu, LI Chun-yu, LI Guo-hui. Regulation of the Pre-metastatic Niches on Lung Cancer Metastasis and Its Clinical Application. Chinese Pharmaceutical Journal, 2020, 55(11): 871-874.
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2020, Vol. 55 
