Research Progress on Stimuli-responsive Polymer-drug Conjugates for Anti-tumor Drugs Delivery
LIU Feng-xi1, FENG Li-xia2, WANG Li-li3, YANG Rui1, SHI Yin-ping1, YAN Hai-ying1, HUANG Xin1*
1. Department of Pharmacy, Shandong Province Qianfoshan Hospital, Jinan 250014, China; 2. Rizhao Central Hospital, Rizhao 276800, China; 3. Shandong Academy of Pharmaceutical Sciences, Jinan 250101, China
Abstract：Polymer-drug conjugates (PDCs) have been extensively studied as nanocarriers for anti-tumor drugs delivery due to excellent stability in circulation and high drug loading ability. Stimuli-responsive PDCs(SRPDCs) could release the loading drug in response to various intra-or extracellular biological stimulis (eg, acidic pH, altered redox potential, and upregulated enzyme), as well as external artificial stimulis (eg, magnetic feld, light, temperature, and ultrasound), which are considered as “smart”nanocarriers for delivery of anti-tumor drugs. In this article, recent progresses in the development of SRPDCs for cancer therapy are reviewed, covering the design, smart linkages as well as responsive drug release property, so as to provide reference for the development of related drug delivery systems. In order to improve the successful translation of stimuli-responsive PDCs, drawbacks and limitations of current researches are discussed, besides, future perspectives and research strategies are also provided.
刘凤喜, 冯立霞, 王丽丽, 杨蕊, 时银萍, 闫海英, 黄欣. 刺激响应型聚合物-药物偶联物用于抗肿瘤药物递送的研究进展[J]. 中国药学杂志, 2019, 54(22): 1817-1821.
LIU Feng-xi, FENG Li-xia, WANG Li-li, YANG Rui, SHI Yin-ping, YAN Hai-ying, HUANG Xin. Research Progress on Stimuli-responsive Polymer-drug Conjugates for Anti-tumor Drugs Delivery. Chinese Pharmaceutical Journal, 2019, 54(22): 1817-1821.
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