Abstract: The tophus is the characteristic feature of advanced gout，which usually causes functional and psychological deficiency，and it always takes a long time for the drug therapy to take effect. Neutrophil extracellular traps（NETs） may lead to the formation of tophus and can limit acute inflammation by degrading cytokines and chemokines.Recently，the improvement of early diagnosis，new drugs and surgical methods can contribute to the prevent of the further destruction of tophaceous gout.

Key words: tophaceous gout, neutrophil extracellular traps, diagnosis, therapy