Research progress on the role of microRNA in diabetic osteoporosis

doi:10.16352/j.issn.1001-6325.2023.02.311

Abstract

Abstract: Diabetic osteoporosis (DOP) is a common bone metabolic disease in patients with diabetes. Under the high glucose (HG) environment, abnormally expressed microRNA (miRNA) interferes with osteogenic differentiation of bone marrow mesenchymal stem cells (BM-MSCs) by regulating key molecules in the Wnt/β-catenin signaling pathway, leading to the occurrence and development of DOP. Exploring the role of miRNA in DOP can provide new ideas for the diagnosis and treatment of DOP.

Key words: diabetes mellitus, osteoporosis, microRNAs, Wnt signaling pathway, mesenchymal stem cells

CLC Number:

R580
R587.2

YANG Mengdi, DING Yulu, WANG Yujie, HE Fengying, SUN Linnan, ZHEN Donghu. Research progress on the role of microRNA in diabetic osteoporosis[J]. Basic & Clinical Medicine, 2023, 43(2): 311-316.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/10.16352/j.issn.1001-6325.2023.02.311

http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2023/V43/I2/311

References 27

[1]	刘中胜, 杨建虹. 未羧化骨钙素对高糖条件下小鼠骨髓间充质干细胞成骨与成脂分化的调控效应[J]. 中国组织工程研究, 2020, 24:2039-2046.
[2]	Zhou P, Li Y, Di R, et al. H19 and Foxc2 synergistically promotes osteogenic differentiation of BMSCs via Wnt-β-catenin pathway[J]. J Cell Physiol, 2019, 234:13799-13806.
[3]	Zheng T, Ji G, Chen J, et al. MicroRNA-142 protects MC3T3-E1 cells against high glucose-induced apoptosis by targeting β-catenin[J]. Exp Ther Med, 2020, 20:125-125.
[4]	郑洁, 郭海英, 潘思京, 等. 表观遗传调控与骨质疏松症的研究进展[J]. 基础医学与临床, 2014, 34:406-409.
[5]	Tang CY, Wu M, Zhao D, et al. Runx1 is a central regulator of osteogenesis for bone homeostasis by orchestrating BMP and WNT signaling pathways[J]. PLoS Genet, 2021, 17:e1009233-e1009233.
[6]	Zhai Z, Chen W, Hu Q, et al. High glucose inhibits osteogenic differentiation of bone marrow mesenchymal stem cells via regulating miR-493-5p/ZEB2 signalling[J]. J Biochem, 2020, 167:613-621.
[7]	He C, Liu M, Ding Q, et al. Upregulated miR-9-5p inhibits osteogenic differentiation of bone marrow mesenchymal stem cells under high glucose treatment[J]. J Bone Miner Metab, 2022, 40:208-219.
[8]	曲野, 刘立柱, 徐瑞敏, 等. miR-295抑制高糖诱导的小鼠成骨细胞系MC3T3-E1的凋亡[J]. 基础医学与临床, 2021, 41:1588-1593.
[9]	Zhang ZD, Ren H, Wang WX, et al. IGF-1R/β-catenin signaling axis is involved in type 2 diabetic osteoporosis[J]. J Zhejiang Univ Sci B, 2019, 20:838-848.
[10]	Li Z, Zhao H, Chu S, et al. miR-124-3p promotes BMSC osteogenesis via suppressing the GSK-3β/β-catenin signaling pathway in diabetic osteoporosis rats[J]. In Vitro Cell Dev Biol Anim, 2020, 56:723-734.
[11]	Cao Y, Qiu Y, Liu MX, et al. miR-29c-3p reduces bone loss in rats with diabetic osteoporosis via targeted regula-tion of Dvl2 expression[J]. Eur Rev Med Pharmacol Sci, 2021, 25:636-642.
[12]	Jiang F, Zong Y, Ma X, et al. miR-26a attenuated bone-specific insulin resistance and bone quality in diabetic mice[J]. Mol Ther Nucleic Acids, 2020, 20:459-467.
[13]	Wang R, Zhang Y, Jin F, et al. High-glucose-induced miR-214-3p inhibits BMSCs osteogenic differentiation in type 1 diabetes mellitus[J]. Cell Death Discov, 2019, 5:143-143.
[14]	Amjadi-Moheb F, Akhavan-Niaki H. Wnt signaling path-way in osteoporosis: epigenetic regulation, interaction with other signaling pathways, and therapeutic promises[J]. J Cell Physiol, 2019, 234:14641-14650.
[15]	Jiating L, Buyun J, Yinchang Z. Role of metformin on osteoblast differentiation in type 2 diabetes[J]. Biomed Res Int, 2019, 2019:9203934.doi:10.1155/2019/9203934.eldlection 2019.
[16]	Wu L, Zhang G, Guo C, et al. Intracellular Ca(2+) signaling mediates IGF-1-induced osteogenic differentiation in bone marrow mesenchymal stem cells[J]. Biochem Biophys Res Commun, 2020, 527:200-206.
[17]	Gan K, Dong GH, Wang N, et al. miR-221-3p and miR-222-3p downregulation promoted osteogenic differentiation of bone marrow mesenchyme stem cells through IGF-1/ERK pathway under high glucose condition[J]. Diabetes Res Clin Pract, 2020, 167:108121.doi:10.1016/j.diabres.2020.108121.
[18]	Varma Shrivastav S, Bhardwaj A, Pathak KA, et al. Insulin-like growth factor binding protein-3 (IGFBP-3): unraveling the role in mediating IGF-independent effects within the cell[J]. Front Cell Dev Biol, 2020, 8:286-286.
[19]	赵丽娟, 李静, 吉淑敏. 糖尿病伴骨质疏松患者血清微小RNA-210胰岛素样生长因子结合蛋白-3的表达及临床价值[J]. 安徽医学, 2019, 40:1131-1134.
[20]	毛竹君, 柴可夫. 淫羊藿-仙茅药对调控miRNA-144保护高糖介导成骨细胞的作用机制[J]. 中华中医药杂志, 2019, 34:965-970.
[21]	王志刚, 刘菊. 利拉鲁肽对2型糖尿病骨质疏松大鼠miRNA-19a、miRNA-144及骨密度的影响[J]. 中国骨质疏松杂志, 2020, 26:1297-1300.
[22]	Zhang W, Wu Y, Shiozaki Y, et al. miRNA-133a-5p inhibits the expression of osteoblast differentiation-associated markers by targeting the 3′ UTR of RUNX2[J]. DNA Cell Biol, 2018, 37:199-209.
[23]	Zhang G, Li H, Zhao W, et al. miR-205 regulates bone turnover in elderly female patients with type 2 diabetes mellitus through targeted inhibition of Runx2[J]. Exp Ther Med, 2020, 20:1557-1565.
[24]	Wang X, Mi Y, He W, et al. Down-regulation of miR-340-5p promoted osteogenic differentiation through regulation of runt-related transcription factor-2 (RUNX2) in MC3T3-E1 cells[J]. Bioengineered, 2021, 12:1126-1137.
[25]	Qu B, He J, Zeng Z, et al. miR-155 inhibition alleviates suppression of osteoblastic differentiation by high glucose and free fatty acids in human bone marrow stromal cells by upregulating SIRT1[J]. Pflugers Arch, 2020, 472:473-480.
[26]	范德生, 甄蕾, 汪黎明. miRNA-31对糖尿病小鼠来源骨髓间充质干细胞体外成骨分化的影响[J]. 口腔颌面外科杂志, 2019, 29:137-141.
[27]	Zhen L, Jiang X, Chen Y, et al. miR-31 is involved in the high glucose-suppressed osteogenic differentiation of human periodontal ligament stem cells by targeting Satb2[J]. Am J Transl Res, 2017, 9:2384-2393.