Research progress on the role of gastric microecology in gastric carcinogenesis

doi:10.16352/j.issn.1001-6325.2022.12.1960

Abstract

Abstract: Human stomach has a unique microbial ecosystem, and the disruption of its homeostasis is closely associated with the development of gastric cancer (GC). Gastric carcinogenesis is correlated with the dysbiosis of gastric mucosal microbiota, which is characterized by the decrease of biologigical diversity and alterations of the composition. The microbiota dysbiosis further induces metabolic disorders and triggers the formation of tumor microenvironment in the stomach which contributes to the development and progression of GC. Exploring the role of gastric micro-ecology in gastric carcinogenesis may provide new insights into the diagnosis and treatment for GC.

Key words: gastric microbiota, gastric cancer, microbiota dysbiosis

CLC Number:

JI Ruo-yu, CAO Xin-yuan, ZHANG Yi-zhen, WANG Qiang, WU Xi, YANG Ying-yun, YANG Ai-ming. Research progress on the role of gastric microecology in gastric carcinogenesis[J]. Basic & Clinical Medicine, 2022, 42(12): 1960-1964.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/10.16352/j.issn.1001-6325.2022.12.1960

http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2022/V42/I12/1960

References

[1]Machlowska J, Baj J, Sitarz M, et al. Gastric cancer: epidemiology, risk factors, classification, genomic characteristics and treatment strategies[J]. Int J Mol Sci, 2020,21:4012. doi:10.3390/ijms21114012.
[2]Sugano K. Effect of Helicobacter pylori eradication on the incidence of gastric cancer: a systematic review and meta-analysis[J]. Gastric Cancer, 2019,22: 435-445.
[3]Li J, Perez Perez GI. Is there a role for the non-Helicobacter pylori bacteria in the risk of developing gastric cancer?[J].Int J Mol Sci, 2018,19: 1-9.
[4]Hu YL, Pang W, Huang Y, et al. The gastric microbiome is perturbed in advanced gastric adenocarcinoma identified through shotgun metagenomics[J]. Front Cell Infect Mi, 2018,8: 433. doi:10.3389/fcimb.2018.00433.
[5]Coker OO, Dai Z, Nie Y, et al. Mucosal microbiome dysbiosis in gastric carcinogenesis[J]. Gut, 2018,67: 1024-1032.
[6]Liu X, Shao L, Liu X, et al. Alterations of gastric mucosal microbiota across different stomach microhabitats in a cohort of 276 patients with gastric cancer[J]. EBioMedicine, 2019,40: 336-348.
[7]Gantuya B, El Serag HB, Matsumoto T, et al. Gastric mucosal microbiota in a Mongolian population with gastric cancer and precursor conditions[J]. Aliment Pharm Ther, 2020,51: 770-780.
[8]Wang Z, Gao X, Zeng R, et al. Changes of the gastric mucosal microbiome associated with histological stages of gastric carcinogenesis[J]. Front Microbiol, 2020,11: 997.doi:10.3389/fmicb.2020.00997.
[9]Ren R, Wang Z, Sun H, et al. The gastric mucosal-associated microbiome in patients with gastric polyposis[J]. Sci Rep, 2018,8: 13817. doi:10.1038/s41598-018-31738-2.
[10]Li TH, Qin Y, Sham PC, et al. Alterations in gastric microbiota after H. pylori eradication and in different histological stages of gastric carcinogenesis[J]. Sci Rep, 2017,7: 44935.doi:10.1038/srep44935.
[11]Jo HJ, Kim J, Kim N, et al. Analysis of gastric micro-biota by pyrosequencing: minor role of bacteria other than Helicobacter pylori in the gastric carcinogenesis[J]. Helicobacter, 2016,21: 364-374.
[12]Yu G, Hu N, Wang L, et al. Gastric microbiota features associated with cancer risk factors and clinical outcomes: a pilot study in gastric cardia cancer patients from Shanxi, China[J]. Int J Cancer, 2017,141: 45-51.
[13]Engstrand L, Graham DY. Microbiome and gastric cancer[J]. Dig Dis Sci, 2020,65: 865-873.
[14]Chen XH, Wang A, Chu AN, et al. Mucosa-associated microbiota in gastric cancer tissues compared with non-cancer tissues[J]. Front Microbiol, 2019,10: 1261. doi:10.3389/fmicb.2019.01261.
[15]Ferreira RM, Pereira-Marques J, Pinto-Ribeiro I, et al. Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota[J]. Gut, 2018,67: 226-236.
[16]Fan X, Alekseyenko AV, Wu J, et al. Human oral microbiome and prospective risk for pancreatic cancer: a population-based nested case-control study[J]. Gut, 2018,67: 120-127.
[17]Flemer B, Warren RD, Barrett MP, et al. The oral microbiota in colorectal cancer is distinctive and predictive[J]. Gut, 2018,67: 1454-1463.
[18]Jakszyn P, Bingham S, Pera G, et al. Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study[J]. Carcinogenesis, 2006,27: 1497-1501.
[19]Hsieh YY, Tung SY, Pan HY, et al.Increased abundance of clostridium and fusobacterium in gastric microbiota of patients with gastric cancer in Taiwan[J]. Sci Rep, 2018,8: 158.doi:0.1038/s41598-017-18596-0.
[20]Zhang X, Li C, Cao W, et al. Alterations of gastric microbiota in gastric cancer and precancerous stages[J]. Front Cell Infect Microbiol, 2021,11: 559148. doi:10.3389/fcimb.2021.559148.
[21]Ippolito L, Morandi A, Giannoni E, et al. Lactate: a metabolic driver in the tumour landscape[J]. Trends Biochem Sci, 2019,44: 153-166.
[22]Nomura M, Nagatomo R, Doi K, et al.Association of short-chain fatty acids in the gut microbiome with clinical response to treatment with nivolumab or pembrolizumab in patients with solid cancer tumors[J]. JAMA Network Open, 2020,3: e202895. doi:10.1001/jamanetworkopen.2020.2895.
[23]Yin J, Ren W, Huang X, et al. Potential mechanisms connecting purine metabolism and cancer therapy[J]. Front Immunol, 2018,9: 1697. doi:10.3389/fimmu.2018.01697.
[24]Sheikh A, Taube J, Greathouse KL. Contribution of the microbiota and their secretory products to inflammation and colorectal cancer pathogenesis: the role of toll-like receptors[J]. Carcinogenesis, 2021,42:1133-1142.
[25]Lofgren JL, Whary MT, Ge Z, et al. Lack of commensal flora in Helicobacter pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia[J]. Gastroenterology, 2011,140: 210-220.