Basic & Clinical Medicine ›› 2022, Vol. 42 ›› Issue (5): 804-808.doi: 10.16352/j.issn.1001-6325.2022.05.010

• Mini Reviews • Previous Articles     Next Articles

Application of anti-HBc quantitative examination in clinical management of chronic hepatitis B virus infection

DU Xin-yi1, MAO Xiao-rong2*, LI Jun-feng2   

  1. 1. The First Clinical Medical College, Lanzhou University, Lanzhou 730000;
    2. Department of Infection, the First Hospital, Lanzhou University, Lanzhou 730000, China
  • Received:2021-06-23 Revised:2021-11-11 Online:2022-05-05 Published:2022-04-28
  • Contact: * mxr2013@126.com

Abstract: The quantification of hepatitis B virus(HBV) core antibody (anti-HBc) is related to host immunity and can be detected in the serum of patients with current or past infections. The antibody against core antigen of HBV plays an important role in the inflammation pathogenesis of liver,evaluation of epidemiology history and of treatment strategy. Chronic HBV infection is closely related to active transcription and persistence of covalently closed circular DNA(cccDNA) in the liver. The result of quantitative anti-HBc antibody examination shows a good correlation with cccDNA level so it is a potential index for comprehensive evaluation of HBV infectious diseases.

Key words: hepatitis B virus(HBV), covalently closed ciecular DNA, quantitative of hepatitis B core antibody, chronic infection

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