基础医学与临床 ›› 2012, Vol. 32 ›› Issue (8): 939-942.

• 研究论文 • 上一篇    下一篇

七氟醚在不同气体流量下代谢产物A物质浓度差异及对患者肝肾功能影响

何凯,叶铁虎   

  1. 中国医学科学院 北京协和医学院 北京协和医院 麻醉科
  • 收稿日期:2012-03-14 修回日期:2012-06-21 出版日期:2012-08-05 发布日期:2012-07-17
  • 通讯作者: 叶铁虎 E-mail:yeth@263.net

Differences of compound A concentrations at low and high sevoflurane flow and its effect on hepatic and renal functions

  • Received:2012-03-14 Revised:2012-06-21 Online:2012-08-05 Published:2012-07-17

摘要: 目的:比较吸入全麻过程中,患者接受相同浓度和时间的七氟醚暴露时,低气体流量(500ml/min)和高气体流量(2L/min)产生A物质(compound A,CA)浓度差异,以及对肝肾功能的影响。方法:将患者(n=40)随机分为高流量组和低流量组。麻醉开始后每隔30min在呼吸管路吸气端取样,检测CA浓度。在术前、术后检测患者的肝肾功能(ALT、AST、Tbil、Dbil、BUN、Cr)。结果:两组患者的七氟醚浓度(0.9692vs0.9675MAC)以及浓度-时间-AUC(2.40vs2.41MAC-h)不存在显著差异;两组CA浓度(27.70vs11.54ppm)和浓度-时间-AUC(55.76vs23.19ppm-h)存在显著差异。两组患者术前、术后的肝肾功能(ALT、AST、Tbil、Dbil、BUN、Cr)无显著改变。结论:低流量(500ml/min)和高流量(2L/min)条件下七氟醚所产生的CA浓度存在显著差异,但不会引起患者肝肾功能指标的改变。

关键词: 麻醉, CO2吸附剂, A物质, 七氟醚

Abstract: Objective: To measure the differences of compound A(CA)between low gas flow(500ml/min)and high gas flow(2L/min),and effects on renal and liver function. Methods:The general surgical patients(n=40)were randomized to low-flow anesthesia group and high-flow anesthesia group. Gas samples were taken from the aspiratory limbs of the anesthetic circuit in 30-minites interval during anesthesia. Analyze CA concentrations. Test the markers of hepatic and renal functions pre- and post-surgery. Results:There were no statistical differences between sevoflurane concentrations(0.97vs0.97MAC)and concentration-time-AUC(2.40vs2.41MAC-h).There were significant differences between concentrations(27.70vs11.54ppm)and concentration-time-AUC(55.76vs23.19ppm-h).All markers of hepatic and renal function(ALT、AST、Tbil、Dbil、BUN、Cr) were unchanged after anesthesia. Conclusion:CA concentrations and concentration-time-AUC between low-flow(500ml/min)and high-flow(2L/min) anesthesia were significantly different,but it did not result in any significant changes to markers of hepatic and renal functions,including、ALT、AST、Tbil、Dbil、BUN and Cr.

Key words: anesthesia, carbon dioxide absorbent, compound A(CA), sevoflurane