基础医学与临床 ›› 2022, Vol. 42 ›› Issue (9): 1428-1432.doi: 10.16352/j.issn.1001-6325.2022.09.1428

• 短篇综述 • 上一篇    下一篇

PI3K信号通路调控动脉粥样硬化发生发展的研究进展

刘珍竹1, 李靖1, 何丹3*, 曲鹏1,2*   

  1. 1. 大连医科大学附属第二医院 心内科,辽宁 大连 116000;
    2. 大连医科大学附属第二医院 心脏及血管疾病研究所,辽宁 大连 116000;
    3. 北京大学医学部基础医学院 生理学与病生理学系 教育部分子心血管重点实验室,北京 100191
  • 收稿日期:2021-02-09 修回日期:2021-07-17 出版日期:2022-09-05 发布日期:2022-09-02
  • 通讯作者: dlhd820120@163.com;qupeng777@aliyun.com
  • 基金资助:
    国家自然科学基金(81670406, 82000415)

Research progress of PI3K signaling pathway regulating the pathogenesis of atherosclerosis

LIU Zhen-zhu1, LI Jing1, HE Dan3*, QU Peng1,2*   

  1. 1. Department of Cardiology, the 2th Affiliated Hospital of Dalian Medical University, Dalian 116000;
    2. Institute of Heart and Vascular Diseases, the 2th Affiliated Hospital of Dalian Medical University, Dalian 116000;
    3. Department of Physiology and Pathophysiology, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, School of Basic Medical Sciences, Peking University, Beijing 100191, China
  • Received:2021-02-09 Revised:2021-07-17 Online:2022-09-05 Published:2022-09-02

摘要: 磷脂酰肌醇3激酶(PI3K)信号通路参与动脉粥样硬化、肿瘤及免疫系统疾病的发生、发展。调节PI3K可以调控细胞凋亡、自噬、炎性反应等病理生理过程,为疾病的治疗提供了新思路。

关键词: 磷脂酰肌醇3激酶(PI3K), 动脉粥样硬化, 免疫炎性反应

Abstract: Phosphatidylinositol 3-kinase(PI3K) signaling pathway is involved in the occurrence and development of atherosclerosis, tumor and immune system diseases. Regulation of PI3K can regulate apoptosis, autophagy, inflammatory response and other pathophysiological processes, which provides a new idea for the treatment of diseases.

Key words: phosphatidylinositol 3-kinase(PI3K), atherosclerosis, immune inflammation

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