基础医学与临床 ›› 2022, Vol. 42 ›› Issue (3): 484-487.doi: 10.16352/j.issn.1001-6325.2022.03.021

• 临床研究 • 上一篇    下一篇

1 169例冻融胚胎移植周期的临床妊娠结局分析

李天凤*, 帅振虹, 张婉菁, 李雪梅   

  1. 南方医科大学附属深圳妇幼保健院 生殖医学中心, 广东 深圳 518048
  • 收稿日期:2021-07-28 修回日期:2021-12-08 出版日期:2022-03-05 发布日期:2022-03-04
  • 通讯作者: * litianfeng119@126.com
  • 基金资助:
    国家自然科学基金青年科学基金(82002633);深圳市卫生健康委员会博士创新(SZBC2018012);广东省医学科研基金(A2019433);深圳市妇幼保健院院内科研基金(FYB2017022)

Clinical pregnancy outcome analysis of 1 169 frozen-thawed embryo transfer cycles

LI Tian-feng*, SHUAI Zhen-hong, ZHANG Wan-jing, LI Xue-mei   

  1. Reproductive Medicine Center, the Affiliated Shenzhen Maternal and Child Healthcare Hospital of Southern Medical University, Shenzhen 518048, China
  • Received:2021-07-28 Revised:2021-12-08 Online:2022-03-05 Published:2022-03-04
  • Contact: * litianfeng119@126.com

摘要: 目的 探讨影响冻融胚胎移植(FET)妊娠结局的相关因素。方法 回顾分析2017年1月至2019年12月在深圳市妇幼保健院行FET的1 169对夫妇的临床数据,采用单因素分析和Logistic多因素回归分析探讨FET妊娠结局的相关因素。结果 1 169个FET周期的临床妊娠率为50.13%;单因素分析表明,年龄>35岁、不孕年限>6年显著降低胚胎种植率和临床妊娠率(P<0.01),但囊胚或多个优胚数目移植可提高胚胎种植率和临床妊娠率(P<0.01);移植多个胚胎提高胚胎种植率(P<0.05),但子宫内膜厚度>12 mm提高临床妊娠率(P<0.05)。多因素Logistic回归分析显示年龄增加和优胚移植数目减少是临床妊娠率的危险因素(P<0.01)。结论 患者年龄和移植优胚数目是影响FET的主要因素;年龄增加是临床妊娠结局的危险因素。

关键词: 冻融胚胎移植(FET), 临床妊娠, 年龄, 胎龄, 优胚数目

Abstract: Objective To investigate the factors in frozen-thawed embryo transfer (FET) cycles that affecting the pregnancy outcome. Methods The clinical data of 1 169 couples who underwent FET in Shenzhen Maternity and Child Healthcare Hospital from January, 2017 to December, 2019 were retrospectively analyzed. Univariate analysis and Logistic multivariate regression analysis were performed to identify the factors which influence pregnancy outcome of FET cycles. Results The clinical pregnancy rate of 1 169 FET cycles was 50.13%. Univariate analysis showed that female patients >35 years old or infertility duration > 6 years significantly had a reduced embryo implantation rate and clinical pregnancy rate (P<0.01). But the embryo implantation rate and clinical pregnancy rate were increased by blastocyst or multiple embryos transfer (P<0.01). Multiple embryo transplantation increased embryo implantation rate (P<0.05) and endometrial thickness >12 mm increased clinical pregnancy rate (P<0.05). Logistic multivariat regression analysis showed that elder age and decreasing number of optimal embryo transplantation were risk factors for clinical pregnancy rate (P<0.01). Conclusions Patients age, embryo age and the number of transplanted embryos of high quality are the main factors affecting the pregnancy outcome of FET. Elder age is a risk factor for clinical pregnancy outcome.

Key words: frozen-thawed embryo transfer(FET), clinical pregnancy, age, embryo age, number of embryos at high quality

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