基础医学与临床 ›› 2022, Vol. 42 ›› Issue (1): 26-32.

• 特邀专题 • 上一篇    下一篇

纳米材料组织工程支架在女性生殖系统再生中的应用研究

胡雪纯1,许海燕2   

  1. 1. 中国医学科学院基础医学研究所
    2. 中国医学科学院 北京协和医学院 基础医学研究所
  • 收稿日期:2021-12-03 修回日期:2021-12-03 出版日期:2022-01-05 发布日期:2022-01-05
  • 通讯作者: 许海燕 E-mail:xuhy@pumc.edu.cn

Research progress of nanomaterials for the female reproductive system tissue engineering

  • Received:2021-12-03 Revised:2021-12-03 Online:2022-01-05 Published:2022-01-05

摘要: 生殖系统的健康与女性生殖能力和生活质量密切相关。近年来女性生殖系统相关疾病发病率日渐升高并呈现年轻化趋势,对女性生殖健康带来诸多不利影响,亟需发展有效的治疗方法。通过组织工程技术引导组织再生,从而实现器官功能的恢复,为相关疾病的治疗提供了新途径。本文对近年来基于纳米结构和生物材料的组织工程支架构建以及组织工程技术在卵巢早衰、卵泡体外培养、子宫宫腔黏连、子宫缺损修复、盆腔器官脱垂等疾病治疗中的应用研究进行回顾总结和综合评述。

Abstract: The health of the reproductive system is closely associated with females’ fertility ability and the quality of life. However, the incidence of diseases related to the female reproductive system has been increasing and the age of onset is becoming younger, generating numerous negative consequences on the female reproductive health. Therefore, there are urgent demands to develop effective therapeutic technologies and strategies. In recent years, the progress of tissue engineering and regenerative medicine has shown promising potentials of novel approaches for the treatment of related diseases by guiding tissue regeneration to restore the organs’ functions. In this article, we introduced the advances of scaffolds construction inspired by nanostructures and biomaterials as well as the applications in the premature ovarian failure, follicle culture in vitro, intrauterine adhesions, and the regeneration of defected uterine and pelvic organ prolapse. In addition, existing challenges and efforts that should be considered in the future were discussed.