基础医学与临床 ›› 2022, Vol. 42 ›› Issue (1): 126-130.

• 研究论文 • 上一篇    下一篇

10661例体检者幽门螺杆菌感染情况及其相关危险因素分析

雷蓉,杨丹,袁芳桃,周小燕,江毅敏,柳弥   

  1. 川北医学院附属医院
  • 收稿日期:2021-03-08 修回日期:2021-05-31 出版日期:2022-01-05 发布日期:2022-01-05
  • 通讯作者: 雷蓉 E-mail:leirong723@163.com
  • 基金资助:
    川北医学院附属医院科研发展项目

An investigation of Helicobacter pylori infection and potential risk factors of colonization found in 10661 cases from routine physical examination

  • Received:2021-03-08 Revised:2021-05-31 Online:2022-01-05 Published:2022-01-05

摘要: 目的:了解健康体检人群幽门螺杆菌感染情况及相关危险因素分析。方法:对2019年1月1日至2020年12月30日在川北医学院附属医院行碳13尿素呼气试验的10661名健康体检人群作为研究对象进行回顾性分析。根据幽门螺杆菌(Helicobacter pylori,H.pylori)感染情况将受检者分为H.pylori阳性组和H.pylori阴性组,分析H.pylori感染与血小板(PLT)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FBG)、T3、T4、TSH、胃蛋白酶原I( pepsinogenⅠ)、胃蛋白酶原II(pepsinogenⅡ)、、胃泌素17、同型半胱氨酸(Hcy)、尿酸(UA)、总胆红素(TBIL)之间的关系。结果:1.阳性感染总人数:4382人,总阳性率:41.10%,其中男性阳性感染例数2717人,阳性率25.49%;女性阳性感染例数1665人,阳性率15.62%,男性高于女性(P<0.05);2.H.pylori阳性组和阴性组相比:阳性组年龄稍高于阴性组(P<0.05),H.pylori阳性组在BMI、收缩压、舒张压、TG、FBG、pepsinogenⅠ、pepsinogenⅡ、G-17、Hcy均高于阴性组(P<0.05);H.pylori阳性组在HDL-C、pepsinogenⅠ/Ⅱ、TBIL均低于阴性组(P<0.05)。PLT、UA、TC、LDL-C、T3、T4、TSH两组相比差异无统计学意义(P>0.05)。3、DOB值高低与年龄、FBG、pepsinogenⅠ、pepsinogenⅡ、G-17呈正相关(P=0.000);DOB值高低与pepsinogenⅠ/Ⅱ、TBIL呈负相关(P=0.000)。4、进一步将P<0.05的参数纳入二元Lojistic回归分析,结果显示年龄、BMI、FBG、TBIL、pepsinogenⅠ、pepsinogenⅡ、pepsinogenⅠ/Ⅱ、Hcy均为幽门螺杆菌感染的危险因素(P<0.05)。结论:H.pylori感染随着年龄增长感染的几率升高,且感染在男性人群中更为常见。二元Lojistic回归分析显示年龄、BMI、FBG、TBIL、pepsinogenⅠ、pepsinogenⅡ、pepsinogenⅠ/Ⅱ、Hcy均为H.pylori感染的危险因素。对这些危险因素进行早期干预有望减少H.pylori的感染,为胃肠道疾病的一级预防提供理论依据。

关键词: 关键词:幽门螺旋杆菌, 碳13尿素呼气试验, 危险因素, 相关性

Abstract: Objective: To investigate the situation of Helicobacter pylori infection in healthy people and analyze the related risk factors. Methods: Retrospective analysis was conducted on 10661 healthy subjects who underwent carbon 13C-UBT on January 1, 2019 solstice and December 30, 2020 in the affiliated hospital of North Sichuan Medical College. According to the infection status of Helicobacter pylori (H.pylori), the subjects were divided into H.pylori positive group and H.pylori negative group. Analysis H.p ylori infection and platelets (PLT), triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG), T3, T4, TSH, pepsinogen Ⅰ, pepsinogen II, and gastric secretion, 17, homocysteine (Hcy), uric acid (UA), the relationship between the total bilirubin (TBIL). Results: 1. The total number of positive infections: 4382, the total positive rate: 41.10%, including 2717 male positive cases, the positive rate: 25.49%; There were 1665 cases of positive infection in females, and the positive rate was 15.62%, which was higher in males than in females (P<0.05). 2. H.p ylori compared to the positive and negative groups: positive age slightly higher than negative group (P < 0.05), H.p ylori positive group in BMI, systolic pressure, diastolic blood pressure, TG, FBG, pepsinogen Ⅰ, pepsinogen Ⅱ, G-17, Hcy were higher than negative group (P < 0.05); H.p ylori positive group in HDL - C, pepsinogen Ⅰ/Ⅱ, TBIL were lower than that of negative group (P < 0.05). There was no significant difference in PLT, UA, TC, LDL-C, T3, T4 and TSH between the two groups (P>0.05). 3, DOB value height and age, FBG, pepsinogen Ⅰ, pepsinogen Ⅱ, G - 17 were positively correlated (P = 0.000); DOB values with the pepsinogen Ⅰ / Ⅱ, TBIL negatively correlated (P = 0.000). 4, further P < 0.05 parameters into binary Lojistic regression analysis, the results showed that age, BMI, FBG, TBIL, pepsinogen Ⅰ, pepsinogen Ⅱ, pepsinogen Ⅰ / Ⅱ, Hcy are a risk factor for helicobacter pylori infection (P < 0.05). Conclusion: The risk of H.pylori infection increases with age, and infection is more common in males. Binary Lojistic regression analysis showed that age, BMI, FBG, TBIL, pepsinogen Ⅰ, pepsinogen Ⅱ, pepsinogen Ⅰ / Ⅱ, Hcy are H.p ylori the risk factors of infection. Early intervention of these risk factors is expected to reduce the infection of H.pylori and provide theoretical basis for the primary prevention of gastrointestinal diseases.