基础医学与临床 ›› 2021, Vol. 41 ›› Issue (8): 1190-1194.

• 短篇综述 • 上一篇    下一篇

心肌特异性microRNA在心肌梗死中作用的研究进展

王强利1, 赵玥1, 国海东1, 王莹2*   

  1. 上海中医药大学 1.基础医学院;2.中药学院,上海 201203
  • 收稿日期:2020-09-14 修回日期:2021-04-09 出版日期:2021-08-05 发布日期:2021-07-21
  • 通讯作者: *wnyn@163.com
  • 基金资助:
    国家自然科学基金(81873366,81703763);上海中医药大学基础学院攀登计划(GY010101)

Progress on the role of cardiac-specific microRNA in myocardial infarction

WANG Qiang-li1, ZHAO Yue1, GUO Hai-dong1, WANG Ying2*   

  1. 1. School of Basic Medical Sciences;2.School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • Received:2020-09-14 Revised:2021-04-09 Online:2021-08-05 Published:2021-07-21
  • Contact: *wnyn@163.com

摘要: 心肌特异性miRNAs,如miR-1、miR-133、miR499和miR208等广泛参与心脏发育和生理病理过程。心肌组织特异性miRNAs不仅参与调控心脏发育早期的心肌分化和后期心肌细胞增殖,同时,心肌特异性miRNAs参与心肌梗死(MI)后的细胞损伤或保护,以及心肌纤维化和心室重构进程;并且能够动员骨髓干细胞入血,促进心肌组织的修复与再生。此外,MI后循环血中心肌特异性miRNAs表达水平明显上调,使其有望成为急性MI早期诊断的确诊指标。

关键词: 心肌特异性microRNAs, 心肌梗死, 心肌保护, 组织再生

Abstract: Cardiac-specific miRNAs, such as miR-1, miR-133, miR499 and miR208, are widely involved in cardiogenesis, physiology and pathology of heart. Cardiac-specific miRNAs are not only involved in cardiomyocyte differentiation in early cardiogenic stages and cardiomyocyte proliferation in the late cardiogenic stages, but also in cell damage or protection, fibrosis, and ventricular remodeling in myocardial infarction (MI) after birth. Meanwhile, cardiac-specific miRNAs can mobilize bone marrow stem cells into the peripheral blood, and promote heart repair and regeneration. In addition, circulating level of cardiac-specific miRNAs are significantly elevated after MI, which makes them to be a promising diagnostic marker for early diagnosis of acute MI.

Key words: cardiac-specific microRNAs, myocardial infarction, myocardial protection, tissue regeneration

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