基础医学与临床 ›› 2021, Vol. 41 ›› Issue (7): 1035-1038.

• 临床研究 • 上一篇    下一篇

老年患者阿司匹林抵抗发生率及其相关危险因素分析

赵艳秋1,梁伟2,洪玉娥1   

  1. 1. 安徽省合肥市第二人民医院
    2. 安徽医科大学第一附属医院肿瘤放疗科
  • 收稿日期:2021-02-03 修回日期:2021-04-19 出版日期:2021-07-05 发布日期:2021-06-17
  • 通讯作者: 梁伟 E-mail:34316801@qq.com
  • 基金资助:
    基于血栓弹力图的高危人群围手术期主要心脑血管不良事件早期预警体系建设探索

Analysis of the incidence and related risk factors of aspirin resistance in elderly patients

  • Received:2021-02-03 Revised:2021-04-19 Online:2021-07-05 Published:2021-06-17

摘要: 目的 探讨老年患者阿司匹林抵抗(aspirin resistance,AR)发生率及其相关危险因素。方法 选取在2016年12月-2020年7月就诊于合肥市第二人民医院的90例老年患者,单一长期口服阿司匹林,服药时间在1年以上,每日剂量100mg,使用血栓弹力图仪检测阿司匹林对血小板的抑制率,同时检验所有患者一般生化指标,并对所获得的结果进行分析。以抑制率<50%记录为阿司匹林抵抗(AR),使用卡方检验评估AR与患者一般情况相关因素的关系。使用多因素Logistic分析老年患者阿司匹林抵抗的独立危险因素。结果 共纳入90例患者,平均年龄(74.06±7.90)岁,AR为17.78%(16/90);AR在年龄、性别、吸烟、肌酐、尿酸等因素组间比较均无统计学差异,而空腹血糖、血小板计数、低密度脂蛋白(LDL)组间有明显差异(P<0.05)。经Logistics分析,空腹血糖和低密度脂蛋白(LDL)与老年患者 AR 发生密切相关(P<0.01,OR=3.97,95% CI=0.89~ 9.71)、(P<0.05,OR=3.11,95% CI=2.42~4.01)。结论 空腹血糖与LDL可能为老年患者AR的独立危险因素。应对此进行积极干预。

关键词: 血栓弹力图, 阿司匹林抵抗, 空腹血糖, 低密度脂蛋白

Abstract: Objective:To investigate the incidence and related risk factors of aspirin resistance (AR) in elderly patients. Methods: Cilincal data of ninety elderly patients who were treated in the Second People's Hospital of Hefei from December 2016 to July 2020 were collected. They took aspirin orally for more than one year with daily dose of 100 mg. The inhibition rate of aspirin on platelet was detected by thromboelastography, and the general biochemical indexes of all patients were tested . The results were analyzed, and the inhibition rate < 50% was recorded as aspirin resistance. Chi square test was used to evaluate the relationship between AR and related factors of patients' general condition. Multivariate logistic analysis was used to analyze the independent risk factors of aspirin resistance in elderly patients. Results:A total of 90 patients were included, the average age was 74.06±7.90 years old, AR was 17.78% (16 / 90); AR had no significant difference in age, gender, smoking, creatinine, uric acid and other factors between groups , but there were significant differences in fasting blood glucose, platelet count, low density lipoprotein (LDL) between groups (P < 0.05). Logistic analysis showed that fasting blood glucose and low density lipoprotein (LDL) were closely related to the occurrence of AR in elderly patients (P < 0.01, OR = 3.97, 95% CI = 0.889-9.714), (P < 0.05, OR = 3.11, 95% CI = 2.42-4.01). Conclusion:Fasting blood glucose and LDL might be independent risk factors of aspirin resistance in elderly patients. Active intervention should be carried out.

Key words: thromboelastography, aspirin resistance, fasting blood glucose, low density lipoprotein

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