• 临床研究 •

老年患者阿司匹林抵抗发生率及其相关危险因素分析

1. 1. 安徽省合肥市第二人民医院
2. 安徽医科大学第一附属医院肿瘤放疗科
• 收稿日期:2021-02-03 修回日期:2021-04-19 出版日期:2021-07-05 发布日期:2021-06-17
• 通讯作者: 梁伟 E-mail:34316801@qq.com
• 基金资助:
基于血栓弹力图的高危人群围手术期主要心脑血管不良事件早期预警体系建设探索

Analysis of the incidence and related risk factors of aspirin resistance in elderly patients

• Received:2021-02-03 Revised:2021-04-19 Online:2021-07-05 Published:2021-06-17

Abstract: Objective：To investigate the incidence and related risk factors of aspirin resistance (AR) in elderly patients. Methods: Cilincal data of ninety elderly patients who were treated in the Second People's Hospital of Hefei from December 2016 to July 2020 were collected. They took aspirin orally for more than one year with daily dose of 100 mg. The inhibition rate of aspirin on platelet was detected by thromboelastography, and the general biochemical indexes of all patients were tested . The results were analyzed, and the inhibition rate < 50% was recorded as aspirin resistance. Chi square test was used to evaluate the relationship between AR and related factors of patients' general condition. Multivariate logistic analysis was used to analyze the independent risk factors of aspirin resistance in elderly patients. Results：A total of 90 patients were included, the average age was 74.06±7.90 years old, AR was 17.78% (16 / 90); AR had no significant difference in age, gender, smoking, creatinine, uric acid and other factors between groups , but there were significant differences in fasting blood glucose, platelet count, low density lipoprotein (LDL) between groups (P < 0.05). Logistic analysis showed that fasting blood glucose and low density lipoprotein (LDL) were closely related to the occurrence of AR in elderly patients (P < 0.01, OR = 3.97, 95% CI = 0.889-9.714), (P < 0.05, OR = 3.11, 95% CI = 2.42-4.01). Conclusion：Fasting blood glucose and LDL might be independent risk factors of aspirin resistance in elderly patients. Active intervention should be carried out.