基础医学与临床 ›› 2021, Vol. 41 ›› Issue (3): 433-437.

• 短篇综述 • 上一篇    下一篇

乳腺癌骨转移分子机制及靶向药物的研究进展

郑亚男,李梅,赵基源   

  1. 宁波大学
  • 收稿日期:2020-04-15 修回日期:2020-07-23 出版日期:2021-03-05 发布日期:2021-03-01
  • 通讯作者: 赵基源 E-mail:zhaojiyuan@nbu.edu.cn
  • 基金资助:
    雌激素受体调控ATBF1蛋白定位 的功能及分子机制研究;矿化物淫羊藿苷-小肠黏膜下层 复合组织工程骨的构建和机制研究

Progress in molecular mechanism and targeted drugs of bone metastases in breast cancer

  • Received:2020-04-15 Revised:2020-07-23 Online:2021-03-05 Published:2021-03-01
  • Contact: Ji-Yuan Zhao E-mail:zhaojiyuan@nbu.edu.cn

摘要: 乳腺癌是威胁全世界女性健康最常见的恶性肿瘤,骨是最容易发生转移的部位。乳腺癌骨转移的分子机制和靶向治疗药物已经成为当前研究的热点。本文归纳了参与调节乳腺癌骨转移的关键分子,并分别从靶向破骨细胞和成骨细胞两个类别对重要的靶向治疗药物进行介绍和疗效比较。

关键词: 乳腺癌, 骨转移, 分子机制, 靶向药物

Abstract: Breast cancer is the most common malignant tumor that threatens the health of women around the world, and bone is the site most prone to metastasis. The molecular mechanism and targeted therapy drugs of bone metastasis in breast cancer have become the current research hotspots. This article summarizes the key molecules involved in regulating bone metastasis of breast cancer. The important targeted therapy drugs are introduced and their efficacy is compared from two categories of targeted osteoclasts and targeted osteoblasts.

Key words: breast cancer, bone metastasis, molecular mechanism, targeted drugs