基础医学与临床 ›› 2021, Vol. 41 ›› Issue (11): 1671-1679.

• 短篇综述 • 上一篇    下一篇

mRNA甲基化与疾病的研究进展

李冉1, 郝延磊2*   

  1. 1.山东大学 齐鲁医学院,山东 济南 250100;
    2.济宁医学院附属医院 神经内科, 山东 济宁 272000
  • 收稿日期:2021-04-08 修回日期:2021-07-31 发布日期:2021-10-27
  • 通讯作者: *yanleihao301@live.com
  • 基金资助:
    国家自然科学基金(81771360)

Research progress on mRNA methylation and diseases

LI Ran1, HAO Yan-lei2*   

  1. 1. Cheeloo College of Medicine, Shandong University, Jinan 250100;
    2. Department of Neurology, the Affiliated Hospital of Jining Medical University, Jining 272000, China
  • Received:2021-04-08 Revised:2021-07-31 Published:2021-10-27
  • Contact: *yanleihao301@live.com

摘要: 包含N6-甲基腺苷(m6A)﹑N5-甲基胞苷(m5C)和N1-甲基腺苷(m1A)等在内的mRNA甲基化修饰占所有mRNA修饰的60%以上,其在mRNA上的分布各不相同。“编码器”“消码器”“读码器”三者参与mRNA甲基化修饰动态可逆的生物学过程,当某一环节出现异常时就会导致肿瘤、病毒感染、代谢、心脏或神经系统等疾病的发生。目前甲基化修饰检测技术繁多,其中应用最为热门的技术就是高通量测序。

关键词: mRNA甲基化, 编码器, 消码器, 读码器, 疾病

Abstract: mRNA methylation modification, including N6-methyladenosine (m6A), N5-methylcytidine (m5C) and N1-methyladenosine (m1A), etc., represents more than 60% of all mRNA modifications and varies distribution on mRNA. “Writers” “erasers” “readers” participate in the dynamic and reversible biological process of mRNA methylation modification, which can lead to tumor, virus infection, metabolism diseases, heart or nervous system diseases, etc. when abnormalities occur in a certain link. At present, there are many methylation modification detection technologies, among which the most popular one is high-throughput sequencing.

Key words: mRNA methylation, writers, erasers, readers, diseases

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