基础医学与临床 ›› 2020, Vol. 40 ›› Issue (12): 1701-1705.

• 短篇综述 • 上一篇    下一篇

子痫前期孕妇外周血游离DNA的研究进展

周嘉怡, 吴逊伟, 戴莉娟, 赵瑰丽, 余波澜*   

  1. 广州医科大学附属第三医院 广东省产科重大疾病重点实验室 广东省母胎医学工程技术研究中心,广东 广州 510150
  • 收稿日期:2019-06-21 修回日期:2020-01-18 出版日期:2020-12-05 发布日期:2020-11-30
  • 通讯作者: * yubolan-q@qq.com
  • 基金资助:
    国家科技部重点研发计划(2018YFC1004104);广州市科技计划重点项目(201804020057);广东省科技厅公益研究与能力建设项目(2019B030316023)

Research progress of peripheral blood free DNA in preeclampsia pregnancy

ZHOU Jia-yi, WU Xun-wei, DAI Li-juan, ZHAO Gui-li, YU Bo-lan*   

  1. Guangdong Maternal-Fetal Medical Engineering Research Center, Guangdong Key Laboratory of Obstetrics and Major Diseases, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China
  • Received:2019-06-21 Revised:2020-01-18 Online:2020-12-05 Published:2020-11-30
  • Contact: * yubolan-q@qq.com

摘要: 妊娠高血压疾病,尤其是子痫前期(PE),是世界范围内孕产妇和围产期发病率和病死率增加的主要原因之一。而孕妇血液胎儿游离的DNA(cff-DNA)可作为早期预测PE的发生发展。并且总结分析cff-DNA与PE的相关性及其可能存在的机制,进一步说明PE的发生可能与DNA甲基化相关,同时探讨其作为生物标志物的局限性,为有效预测子痫前期提供参考。

关键词: 外周游离核酸, 子痫前期, 生物标志物

Abstract: Pregnancy-induced hypertension, especially preeclampsia (PE), is one of the leading causes of increased maternal and perinatal morbidity and mortality worldwide. And the circulating cell free fetal nucleic acid (cff-DNA) analysis of pregnant women can be used as an early prediction of the occurrence and development of PE. By summarizing and analyzing the correlation between cff-DNA and PE and its possible mechanism, this paper further explained that the occurrence of PE may be related to DNA methylation, and discussed its limitations as a biomarker, so as to provide reference for the effective prediction of preeclampsia.

Key words: cell free fetal nucleic acid, preeclampsia, biomarker

中图分类号: